17660-55-8

Basic information

• Product Name: 2,3-bis(acetylsulfanyl)butanedioic acid
• CAS NO: 17660-55-8
• Molecular Formula: C₈H₁₀O₆S₂
• Molecular Weight: 266.2914
• Mol File: 17660-55-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 359.2°C at 760 mmHg
• Flash Point: 171°C
• Density: 1.541g/cm³
• Vapor Pressure: 3.92E-06mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 2,3-bis(acetylsulfanyl)butanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(acetylsulfanyl)butanedioic acid(17660-55-8)
• EPA Substance Registry System: 2,3-bis(acetylsulfanyl)butanedioic acid(17660-55-8)

Safety Data

• Hazardous Substances Data: 17660-55-8(Hazardous Substances Data)

Usage

General Description

2,3-bis(acetylsulfanyl)butanedioic acid, also known as 2,3-butanedioic acid di(acetylsulfanyl) ester, is a chemical compound with the molecular formula C8H12O6S2. It is a diester derivative of butanedioic acid, containing two acetylsulfanyl groups. 2,3-bis(acetylsulfanyl)butanedioic acid is primarily used in organic synthesis and chemical research as a building block for creating other organic molecules. It is known for its potential applications in pharmaceuticals and as a reagent in chemical reactions. 2,3-bis(acetylsulfanyl)butanedioic acid is typically handled and stored under specific safety precautions to prevent exposure and ensure its stability.

Upstream product

• 507-09-5 thioacetic acid 
• 141-78-6 ethyl acetate 
• 142-45-0 Acetylenedicarboxylic acid 
• 507-09-5 tiolacetic acid 
• 928-04-1 Dikaliumsalz von Acetylendicarbonsaeure 

Downstream Products

• 2418-14-6 2,3-dimercapto-succinic acid 
• 304-55-2 racemic-2,3-dimercaptosuccinic acid 

Relevant articles and documents

Dimercaptosuccinic acid and salt thereof and preparation method

The invention relates to the technical field of organic synthesis, in particular to dimercaptosuccinic acid and salt thereof and a preparation method. The preparation method comprises the following steps: carrying out reaction on ethyl xanthate and 2,3-dibromosuccinic acid, so that 2,3-diethyl xanthate-1,4 succinic acid is obtained; hydrolyzing the 2,3-diethyl xanthate-1,4 succinic acid, so that 2,3-dimercaptosuccinate solution is obtained; and acidifying the obtained 2,3-dimercaptosuccinate solution, so that 2,3-dimercaptosuccinic acid is obtained. The preparation method provided by the invention has the advantages that technology is simple, liquid-state thioacetic acid with strong odor and unstable quality does not need to be used, unsafe addition reaction does not need to be carried out, preparation period is short, yield is high, cost is low, and the dimercaptosuccinic acid can be applicable to industrial production and popularization and can be further prepared into a dimercaptosuccinate product. The dimercaptosuccinic acid product and the dimercaptosuccinate product are high in purity and low in cost.

Comparative in vivo lead mobilization of meso- and rac-2,3-dimercaptosuccinic acids in albino Wistar rats

Comparison of the racemic and meso forms of 2,3-dimercaptosuccinic acid (DMSA) in lead mobilization from lead-loaded albino Wistar rats demonstrates that the racemic form is significantly more effective in reducing femur lead levels. After four oral doses at 0.5 mmol/kg, femur lead levels were reduced to 87% of control values by meso-DMSA and to 50% of control levels by rac-DMSA. Similarly, when the dose was increased to 1.0 mmol/kg, femur lead levels were reduced to 69% of control levels by meso-DMSA and to 45% of control levels by rac-DMSA. A similar pattern was found for renal lead levels. Brain lead concentrations were significantly lower in treated groups than in control groups, but no differences were found between rac- and meso-DMSA. Rac-DMSA is more soluble than meso-DMSA in acetonitrile, ethyl acetate, and ethyl ether. The partition coefficient of rac-DMSA in the n-octanol/water system was found to be about 2.8. These results indicate that rac-DMSA deserves further attention as a possible substitute for meso-DMSA.