176961-26-5

Basic information

• Product Name: [1,1'-Biphenyl]-2-sulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(1-methyl- 1H-imidazol-2-yl)-
• CAS NO: 176961-26-5
• Molecular Formula: C25H28N4O5S
• Molecular Weight: 496.587
• Mol File: 176961-26-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [1,1'-Biphenyl]-2-sulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(1-methyl- 1H-imidazol-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-2-sulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(1-methyl- 1H-imidazol-2-yl)-(176961-26-5)
• EPA Substance Registry System: [1,1'-Biphenyl]-2-sulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(1-methyl- 1H-imidazol-2-yl)-(176961-26-5)

Safety Data

• Hazardous Substances Data: 176961-26-5(Hazardous Substances Data)

Upstream product

• 176961-13-0 2-borono-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-benzenesulfonamide 
• 176961-54-9 (1-methyl-1H-imidazol-2-yl)bromobenzene 
• 497-19-8 sodium carbonate 
• 1066-33-7 ammonium bicarbonate 
• 176960-47-7 N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 

Relevant articles and documents

Biphenylsulfonamide endothelin receptor antagonists. Part 3: Structure-activity relationship of 4′-heterocyclic biphenylsulfonamides

A number of 4′-heterocyclic biphenylsulfonamide derivatives, formally derived from BMS-193884 (1) by replacing the oxazole ring with other heterocyclic rings, are potent and selective endothelin A (ETA) receptor antagonists. Among the analogues examined, the pyrimidine derivative 18 is the most potent (Ki=0.9 nM) and selective for the ETA receptor, approximately equivalent to 1.

SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES

Compounds of the formula STR1 inhibit the activity of endothelin. The symbols are defined as follows: R 1, R 2, R 3 and R 4 are each directly bonded to a ring carbon and are each independently(a) hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy,