176961-54-9

Basic information

• Product Name: 2-(4-bromophenyl)-1-methyl-1H-imidazole
• Synonyms: 2-(4-bromophenyl)-1-methyl-1H-imidazole
• CAS NO: 176961-54-9
• Molecular Formula: C₁₀H₉BrN₂
• Molecular Weight: 237.09586
• Mol File: 176961-54-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-bromophenyl)-1-methyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-1-methyl-1H-imidazole(176961-54-9)
• EPA Substance Registry System: 2-(4-bromophenyl)-1-methyl-1H-imidazole(176961-54-9)

Safety Data

• Hazardous Substances Data: 176961-54-9(Hazardous Substances Data)

Usage

Imidazole family

A five-membered nitrogen-containing ring This describes the structure of the compound, which is a member of the imidazole family and consists of a five-membered nitrogen-containing ring.

Building block in synthesis

Used in the synthesis of pharmaceuticals and other organic compounds This indicates that the compound is commonly used as a building block or precursor in the synthesis of other compounds, particularly in the pharmaceutical industry.

Biological activity

Exhibits antiviral, antifungal, and antibacterial properties This describes the compound's reported biological activity, which includes its ability to inhibit the growth of viruses, fungi, and bacteria.

Potential applications

In the development of new drugs, materials science, and as a precursor to various heterocyclic compounds This describes the potential applications of the compound, which include its use in the development of new drugs, as well as in materials science and as a precursor to other compounds.

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 589-87-7 1,4-bromoiodobenzene 

Downstream Products

• 1394371-78-8 (3R,3aR,6R,6aR)-6-[[6-chloro-5-[4-[4-(1-methylimidazol-2-yl)phenyl]phenyl]-1H-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 
• 186551-66-6 (1-methyl-1H-imidazol-2-yl)benzene-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide 
• 186551-65-5 (1-methyl-1H-imidazol-2-yl)benzene-4-sulfonyl chloride 
• 176961-26-5 N-(3,4-Dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(1-methyl-1H-imidazole-2-yl)[1,1'-biphenyl]-2-sulfonamide 

Relevant articles and documents

Sulfonamidopyrrolidinone factor Xa inhibitors: Potency and selectivity enhancements via P-1 and P-4 optimization

Sulfonamidopyrrolidinones were previously disclosed as a selective class of factor Xa (fXa) inhibitors, culminating in the identification of RPR120844 as a potent member with efficacy in vivo. Recognizing the usefulness of the central pyrrolidinone template for the presentation of ligands to the S-1 and S-4 subsites of fXa, studies to optimize the P-1 and P-4 groups were initiated. Sulfonamidopyrrolidinones containing 4-hydroxy- and 4- aminobenzamidines were discovered to be effective inhibitors of fXa. X-ray crystallographic experiments in trypsin and molecular modeling studies suggest that our inhibitors bind by insertion of the 4-hydroxybenzamidine moiety into the S-1 subsite of the fXa active site. Of the P-4 groups examined, the pyridylthienyl sulfonamides were found to confer excellent potency and selectivity especially in combination with 4-hydroxybenzamidine. Compound 20b (RPR130737) was shown to be a potent fXa inhibitor (K1 = 2 nM) with selectivity against structurally related serine proteinases (> 1000 times). Preliminary biological evaluation demonstrates the effectiveness of this inhibitor in common assays of thrombosis in vitro (e.g. activated partial thromboplastin time) and in vivo (e.g. rat FeCl2-induced carotid artery thrombosis model).