17736-20-8 Usage
Description
3alpha,17,21-trihydroxy-5beta-pregnane-11,20-dione 21-acetate, also known as 5β-Pregnan-3α,17α,21-triol-11,20-dion-21-acetate, is a steroidal derivative with a unique molecular structure characterized by the presence of three hydroxyl groups at the 3alpha, 17, and 21 positions, and an acetate group at the 21 position. It belongs to the pregnane family of steroids and exhibits specific chemical and biological properties.
Uses
Used in Pharmaceutical Industry:
3alpha,17,21-trihydroxy-5beta-pregnane-11,20-dione 21-acetate is used as an intermediate compound in the synthesis of cortisone derivatives, which are essential for the development of various pharmaceutical products. These cortisone derivatives possess anti-inflammatory, immunosuppressive, and glucocorticoid properties, making them valuable for treating a wide range of medical conditions, including rheumatoid arthritis, asthma, and various autoimmune disorders.
Additionally, due to its unique structure and functional groups, 3alpha,17,21-trihydroxy-5beta-pregnane-11,20-dione 21-acetate may also have potential applications in other areas of the pharmaceutical industry, such as the development of new drugs targeting specific receptors or pathways, or as a component in drug delivery systems to improve the bioavailability and efficacy of other therapeutic agents. Further research and development are required to fully explore and exploit the potential applications of this steroidal derivative.
Check Digit Verification of cas no
The CAS Registry Mumber 17736-20-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,3 and 6 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 17736-20:
(7*1)+(6*7)+(5*7)+(4*3)+(3*6)+(2*2)+(1*0)=118
118 % 10 = 8
So 17736-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H34O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h14-17,20,25,28H,4-12H2,1-3H3/t14-,15-,16+,17+,20-,21+,22+,23+/m1/s1
17736-20-8Relevant articles and documents
C-3 GLUCOSIDURONATES OF METABOLITES OF ADRENAL STEROIDS
Mattox, Vernon R.,Goodrich, June E.,Nelson, Albert N.
, p. 23 - 34 (1982)
On treatment with methyl 2,3,4-tri-O-acetyl-1-bromo-1-deoxy-α-D-glucuronate and silver carbonate, tetrahydrocortisone 21-acetate gave the corresponding 3-glucosiduronate triacetyl methyl ester.This product was converted into the 20-semicarbazone which, by treatment with alkali to hydrolyze the ester functions and acid to hydrolyze the semicarbazone moiety, gave tetrahydrocortisone 3-glucosiduronic acid.The acid was converted into the crystalline barium salt and into the methyl ester.An analogous series of reactions was carried out on tetrahydrocortexolone 21-acetate.Treatment of the 20-semicarbazone of tetrahydrocortisone 3-glucosiduronic acid with potassium borohydride reduced the 11-oxo function to an 11β hydroxyl group; acid-catalyzed removal of the semicarbazone group produced tetrahydrocortisol 3-glucosiduronic acid which also was obtained as the barium salt and the methyl ester.
Synthesis of haptens for use in immunoassay of tetrahydrocortisol, tetrahydrocortisone and their glucuronides
Hosoda,Saito,Ito,et al.
, p. 2110 - 2118 (2007/10/02)
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