26312-91-4 Usage
Description
TETRAHYDROCORTISONE 3-(B-D-GLUCURONIDE) is a glucuronide conjugate of Tetrahydrocortisone, a metabolite of Cortisone, which is a hormone naturally produced in the adrenal cortex. TETRAHYDROCORTISONE 3-(B-D-GLUCURONIDE) plays a significant role in the metabolism and excretion of Cortisone, aiding in the regulation of various physiological processes in the body.
Uses
Used in Pharmaceutical Industry:
TETRAHYDROCORTISONE 3-(B-D-GLUCURONIDE) is used as a pharmaceutical intermediate for the synthesis of various corticosteroid drugs. It serves as a key component in the development of medications targeting inflammation, immune response modulation, and hormone replacement therapy.
Used in Research and Development:
In the field of medical research, TETRAHYDROCORTISONE 3-(B-D-GLUCURONIDE) is utilized as a research compound to study the metabolism, pharmacokinetics, and pharmacodynamics of corticosteroids. This helps scientists understand the mechanisms of action and potential therapeutic applications of these drugs.
Used in Diagnostic Applications:
TETRAHYDROCORTISONE 3-(B-D-GLUCURONIDE) can be employed as a biomarker in diagnostic tests to monitor the levels of Cortisone and its metabolites in the body. This aids in the assessment of adrenal function and the effectiveness of corticosteroid treatments.
Used in Toxicology Studies:
TETRAHYDROCORTISONE 3-(B-D-GLUCURONIDE) is also used in toxicology studies to evaluate the potential adverse effects of corticosteroids and their metabolites on various organs and systems. This information is crucial for the safe and effective use of corticosteroid medications.
Check Digit Verification of cas no
The CAS Registry Mumber 26312-91-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,3,1 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 26312-91:
(7*2)+(6*6)+(5*3)+(4*1)+(3*2)+(2*9)+(1*1)=94
94 % 10 = 4
So 26312-91-4 is a valid CAS Registry Number.
26312-91-4Relevant articles and documents
A novel synthesis of tetrahydrocortisone 3-glucuronide
Aisa, Haji A.,Jiang, Xiangrui,Li, Rui,Shen, Jingshan,Zhang, Suqing,Zhang, Yan
, (2022/01/19)
A new route for the synthesis of tetrahydrocortisone 3-glucuronide has been developed with cortisone acetate as a starting material. The key step was using lithium tri-tert-butoxyaluminum hydride to reduce the C-3 carbonyl group of 5β-dihydrocortisone acetate (8) to provide 3α-5β-tetrahydrocortisone acetate (5). Then, Koenig–Knorr method was used for glycosylation with glycosyl bromide as the donor, cadmium carbonate as promoter and 4? molecular sieves as dehydrating agent to give high yield of the desired product. The new route is shorter and gives higher yield than that reported in the literature.
C-3 GLUCOSIDURONATES OF METABOLITES OF ADRENAL STEROIDS
Mattox, Vernon R.,Goodrich, June E.,Nelson, Albert N.
, p. 23 - 34 (2007/10/02)
On treatment with methyl 2,3,4-tri-O-acetyl-1-bromo-1-deoxy-α-D-glucuronate and silver carbonate, tetrahydrocortisone 21-acetate gave the corresponding 3-glucosiduronate triacetyl methyl ester.This product was converted into the 20-semicarbazone which, by treatment with alkali to hydrolyze the ester functions and acid to hydrolyze the semicarbazone moiety, gave tetrahydrocortisone 3-glucosiduronic acid.The acid was converted into the crystalline barium salt and into the methyl ester.An analogous series of reactions was carried out on tetrahydrocortexolone 21-acetate.Treatment of the 20-semicarbazone of tetrahydrocortisone 3-glucosiduronic acid with potassium borohydride reduced the 11-oxo function to an 11β hydroxyl group; acid-catalyzed removal of the semicarbazone group produced tetrahydrocortisol 3-glucosiduronic acid which also was obtained as the barium salt and the methyl ester.
