1777-55-5

Basic information

• Product Name: Ethanone, 1-(4-methoxyphenyl)-2-(triphenylphosphoranylidene)-
• Synonyms: 1-(4-methoxyphenyl)-2-(triphenylphosphonylidene)ethanone;1-(4-methoxyphenyl)-2-(triphenylphosphoranylidene)ethanone;((4-methoxyphenyl)carbonylmethylene)triphenylphosphorane;4-methoxy benzoyl methylene triphenyl phosphorane;1-(4-methoxyphenyl)-2-(triphenylphosphosphanylidene)ethanone
• CAS NO: 1777-55-5
• Molecular Formula: C27H23O2P
• Molecular Weight: 410.452
• Mol File: 1777-55-5.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-methoxyphenyl)-2-(triphenylphosphoranylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-methoxyphenyl)-2-(triphenylphosphoranylidene)-(1777-55-5)
• EPA Substance Registry System: Ethanone, 1-(4-methoxyphenyl)-2-(triphenylphosphoranylidene)-(1777-55-5)

Safety Data

• Hazardous Substances Data: 1777-55-5(Hazardous Substances Data)

Upstream product

• 17614-89-0 (2-(4-methoxyphenyl)-2-oxoethyl)triphenylphosphonium bromide 
• 26088-49-3 [(4-methoxybenzoyl)(phenylthiocarbamoyl)methylene]triphenylphosphorane 
• 603-35-0 triphenylphosphine 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 19233-55-7 2-Chloro-1-(4-methoxy-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone 
• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 
• 91585-32-9 ((4-methoxyphenyl)ethynyl)(phenyl)selane 
• 22966-19-4 trans-4'-methoxychalcone 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 1256284-89-5 1-(4-methoxyphenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone 
• 1301603-41-7 (2E)-3-(7-fluoro-1,4-dioxoquinoxalin-2-yl)-1-(4-methoxyphenyl)propenone 
• 1301603-42-8 (2E)-3-(7-chloro-1,4-dioxoquinoxalin-2-yl)-1-(4-methoxyphenyl)propenone 
• 1301603-43-9 (2E)-1-(4-methoxyphenyl)-3-(7-methyl-1,4-dioxoquinoxalin-2-yl)propenone 
• 1301603-44-0 (2E)-3-(6,7-difluoro-1,4-dioxoquinoxalin-2-yl)-1-(4-methoxyphenyl)propenone 
• 85108-60-7 (2E)-3-(1,4-dioxoquinoxalin-2-yl)-1-(4-methoxyphenyl)propenone 
• 947753-28-8 [(4-methoxybenzoylmethylenetriphenylphosphorane)HgI₂]2 
• 156167-69-0 Methyl 2-methoximino-2-{2-[3-oxo-3-(4-methoxyphenyl)prop-(E)1-enyl]-phenyl}-acetate 
• 5711-41-1 3-(4-methoxybenzoyl)acrylic acid 

Relevant articles and documents

Substituent effects in the formation of a few acenaphthenone-2-ylidene ketones and their molecular docking studies and in silico ADME profile

We observed intriguing substituent effects in the reaction between 4-substituted acetophenones and acenaphthenequinone in the presence of KOH in methanol. In all cases, expected Claisen-Schimdt condensation was the first step. However, depending on the nature of 4-substituent on acetophenone, the initially formed condensation product remain unchanged or underwent Domino sequence of reactions to give three different 2:2 adducts arising through three distinct pathways. The interactions of acenaphthenone-2-ylidene ketones with the target proteins were performed by molecular docking studies. The prediction of in silico ADME belongings of the synthesized compounds revealed substantial drug-likeness characters based on Lipinski's rules.

The Influence of Substitution on Thiol-Induced Oxanorbornadiene Fragmentation

Oxanorbornadienes (ONDs) undergo facile Michael addition with thiols and then fragment by a retro-Diels-Alder (rDA) reaction, a unique two-step sequence among electrophilic cleavable linkages. The rDA reaction rate was explored as a function of the furan

C(sp2)-H Bond Multiple Functionalization in Air for Construction of Tetrahydrocarbazoles with Continuous Quaternary Carbons and Polycyclic Diversification

The C(sp2)-H function of indole ketone with diazo compound via a rhodium(II)-catalyzed intramolecular electrophilic trapping reaction under mild conditions in air was demonstrated. The established methodology provided a highly efficient approach for direct synthesis of mutisubstituted tetrahydrocarbazoles with continuous quaternary carbons. The resulting products facilitate further modification to conveniently construct tetrahydrocarbazoles with additional fused heterocyclic rings. By phenotypic screening, several products exhibit good anticancer bioctivities in osteosarcoma cell lines.