7448-86-4Relevant articles and documents
Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation
Paucar, Rocío,Martín-Escolano, Rubén,Moreno-Viguri, Elsa,Azqueta,Cirauqui,Marín, Clotilde,Sánchez-Moreno, Manuel,Pérez-Silanes, Silvia
, p. 3902 - 3917 (2019)
The current chemotherapy against Chagas disease is inadequate and insufficient. A series of ten Mannich base-type derivatives have been synthesized to evaluate their in vitro antichagasic activity. After a preliminary screening, compounds 7 and 9 were sub
Rongalite as C1 Synthon and Sulfone Source: A Practical Sulfonylmethylation Based on the Separate-Embedding Strategy
Chen, Xiang-Long,Wu, Chun-Yan,Ma, Jin-Tian,Zhuang, Shi-Yi,Yu, Zhi-Cheng,Wu, Yan-Dong,Wu, An-Xin
supporting information, p. 223 - 227 (2022/01/04)
Rongalite has been used in several challenging synthetic transformations with operationally simple and effective protocols. However, the employment of multiple characteristics of rongalite in synthetic chemistry is comparatively little known. Herein we report a separate-embedding type sulfonylmethylation of sulfoxonium ylides in which rongalite concurrently acted as a sulfone source, C1 synthon, radical initiator, and potential reducing reagent for the first time. Notably, this facile and easy-handling reaction does not require a catalyst or prefunctionalized sulfonylmethylation reagents.
Metabolically stable vanillin derivatives for the treatment of hypoxia
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Page/Page column 12-14, (2021/09/01)
Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
Enantioselective Copper-Catalyzed Electrophilic Sulfenylation of Cyclic Imino Esters
Chen, Zhiwei,Lin, Huaxin,Han, Jian,Fang, Dongmei,Wang, Min,Liao, Jian
supporting information, p. 9146 - 9150 (2021/11/30)
Herein we report an enantioselective sulfenylation of cyclic imino esters with the efficient and versatile sulfenylation reagent S-alkyl 4-methylbenzenesulfonothioates. By utilizing the Cu/tBu-Phosferrox catalytic system, we can assemble diverse S-alkyl groups into the cyclic imino esters under mild conditions in good yields and with excellent enantioselectivities. Remarkably, this method demonstrates a high tolerance of diverse functional groups and proves to be applicable in the late-stage functionalization of pharmaceuticals.