81112-07-4

Basic information

• Product Name: 1-Propanone, 2-chloro-1-(4-methoxyphenyl)- (9CI)
• Synonyms: 1-Propanone, 2-chloro-1-(4-methoxyphenyl)- (9CI);1-Propanone, 2-chloro-1-(4-Methoxyphenyl)-
• CAS NO: 81112-07-4
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.64614
• Product Categories: ACETYLHALIDE
• Mol File: 81112-07-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Propanone, 2-chloro-1-(4-methoxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-chloro-1-(4-methoxyphenyl)- (9CI)(81112-07-4)
• EPA Substance Registry System: 1-Propanone, 2-chloro-1-(4-methoxyphenyl)- (9CI)(81112-07-4)

Safety Data

• Hazardous Substances Data: 81112-07-4(Hazardous Substances Data)

Usage

Chemical Class

The compound belongs to the ketone and chloroarene classes of compounds.

Molecular Weight

The molecular weight of the compound is 202.644 g/mol.

Uses

The compound is primarily used in the synthesis of various pharmaceuticals and organic compounds.

Reactivity

As a ketone, the compound has a carbonyl group, which makes it reactive and useful in a variety of chemical reactions.

Hazards

It is important to handle this chemical with care, as it can be hazardous if not used properly.

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 74-88-4 methyl iodide 
• 85157-85-3 (Z)-1-chloro-1-(4-methoxyphenyl)-1-propene 
• 710949-40-9 2-chloro-1,3-bis(4′-methoxy-phenyl)-1,3-propanedione 
• 121-97-1 4-Methoxypropiophenone 
• 7623-09-8 2-chloropropionyl chloride 
• 100-66-3 methoxybenzene 

Downstream Products

• 94996-39-1 4-Methoxy-α-<2-aethyl-phenoxy>-propiophenon 
• 93878-38-7 4-Methoxy-α-<4-acetyl-phenoxy>-propiophenon 
• 97080-54-1 4-Methoxy-α-<4-propionyl-phenoxy>-propiophenon 
• 1219705-55-1 (Z)-2-(4-methoxyphenyl)-1-methyl-1,4-pentadiene 
• 942-54-1 2-(4-methoxyphenyl)propanoic acid 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 50415-73-1 methyl 2-(4-methoxyphenyl)propionate 
• 2901-41-9 2-(4-methoxyphenyl)ethyl propionate 
• 82461-55-0 2-methoxy-1-(4-methoxy-phenyl)-propan-1-one 
• 121-97-1 4-Methoxypropiophenone 
• 15482-28-7 2-hydroxy-1-(4-methoxyphenyl)-propan-1-one 
• 93434-69-6 1-(4-methoxyphenyl)-2-phenoxypropan-1-one 
• 94996-38-0 4-Methoxy-α-<3-aethyl-phenoxy>-propiophenon 
• 94996-40-4 4-Methoxy-α-<4-aethyl-phenoxy>-propiophenon 

Relevant articles and documents

Synthesis and reactivity of α-sulfenyl-β-chloroenones, including oxidation and Stille cross-coupling to form chalcone derivatives

The synthesis of a range of novel α-sulfenyl-β-chloroenones from the corresponding α-sulfenylketones, via a NCS mediated chlorination cascade, is described. The scope of the reaction has been investigated and compounds bearing alkyl- and arylthio substituents have been synthesised. In most instances, the Z α-sulfenyl-β-chloroenones were formed as the major products, while variation of the substituent at the β-carbon position led to an alteration in stereoselectivity. Stille cross-coupling with the Z α-sulfenyl-β-chloroenones led to selective formation of Z sulfenyl chalcones, while the E α-sulfenyl-β-chloroenones did not react under the same conditions. Oxidation of the Z α-sulfenyl-β-chloroenones was followed by isomerisation, leading to the E α-sulfinyl-β-chloroenones. Stille cross-coupling with the E α-sulfinyl-β-chloroenones produced the E sulfinyl chalcones. Either the E or Z sulfinyl chalcones can be obtained by altering the sequence of oxidation and Stille cross-coupling.

Iodine(III)-Mediated Oxidative Hydrolysis of Haloalkenes: Access to α-Halo Ketones by a Release-and-Catch Mechanism

An unprecedented iodine(III)-mediated oxidative transposition of vinyl halides has been accomplished. The products obtained, α-halo ketones, are useful and polyvalent synthetic precursors. There are only a handful of reported examples of the direct conversion of vinyl halides to their corresponding α-halo carbonyl compounds. Insights into the mechanism and demonstration that this synthetic transformation can be done under enantioselective conditions are reported.

Photocyclization of 2-chloro-substituted 1,3-diarylpropan-1,3-diones to flavones

The photochemical behavior of 2-halo-substituted 1,3-diarylpropan-1,3-dione strongly depends on the nature of the halogen atom bonded and the presence of electron-donor groups on the phenyl ring. In the case of 2-chloro-1,3- diphenylpropan-1,3-dione and 1-(3,5-dimethoxyphenyl)-3-phenylpropan-1,3-dione, cyclization to flavones was the sole reaction pathway, whereas in the case of 2-chloro-1,3-di(4-methoxyphenyl)-propan-1,3-dione, only products derived from α-cleavage were observed. 2-Fluoro derivatives of 1,3-diarylpropan-1,3- diones were photostable; on the other hand, 2-chloro-2-fluoro derivates resulted in 3-fluoroflavones.