177966-63-1 Usage
Description
FMOC-D-4-Nitrophe, also known as Fmoc-4-nitro-D-phenylalanine, is an alanine derivative that plays a significant role in chemical synthesis and peptide chemistry. It is a crucial component in the development of various pharmaceutical compounds and has unique properties that make it valuable in the field of biochemistry.
Uses
Used in Pharmaceutical Industry:
FMOC-D-4-Nitrophe is used as a building block for the synthesis of various pharmaceutical compounds. Its incorporation into peptide structures allows for the development of new drugs with specific therapeutic properties, targeting a wide range of medical conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, FMOC-D-4-Nitrophe is used as a key intermediate for the production of complex molecules. Its unique structure enables the creation of novel compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Peptide Chemistry:
FMOC-D-4-Nitrophe is used as a crucial component in peptide chemistry, where it is employed in the synthesis of peptides and peptide-based drugs. Its presence in peptide sequences can influence the overall properties of the peptide, such as stability, solubility, and biological activity, making it an essential tool for peptide research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 177966-63-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,9,6 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 177966-63:
(8*1)+(7*7)+(6*7)+(5*9)+(4*6)+(3*6)+(2*6)+(1*3)=201
201 % 10 = 1
So 177966-63-1 is a valid CAS Registry Number.
InChI:InChI=1/C24H20N2O6/c27-23(28)22(13-15-9-11-16(12-10-15)26(30)31)25-24(29)32-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,25,29)(H,27,28)/t22-/m0/s1
177966-63-1Relevant articles and documents
Two novel amino acid derivatives containing side-chain thioamides for the synthesis of photoactivatable peptides
Singh, Preeti,Hurrell, Craig R.,Findlay, John B. C.,Fishwick, Colin W. G.
, p. 715 - 718 (1997)
The highly efficient preparation of two optically pure phenylalanine analogues containing p-N-aryl thiobenzamide moieties are described. These amino acids are readily incorporated into peptides via standard solid-phase strategies.
Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified d-phenylalanine residues
van der Knaap, Matthijs,Engels, Eefje,Busscher, Henk J.,Otero, Jose M.,Llamas-Saiz, Antonio L.,van Raaij, Mark J.,Mars-Groenendijk, Roos H.,Noort, Daan,van der Marel, Gijsbert A.,Overkleeft, Herman S.,Overhand, Mark
scheme or table, p. 6318 - 6328 (2011/02/26)
The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified d-phenylalanine residue, their antibacterial properties against several Gram positive and negative strains, as well as their hemolytic activity is reporte
α,α-difluorophosphonomethyl azobenzene derivatives as photoregulated phosphoamino acid analogs. 1. Design and synthesis
Park, Seung Bum,Standaert, Robert F.
, p. 6557 - 6560 (2007/10/03)
A series of novel, photoregulated phosphoamino acid analogs based on an azobenzene core bearing an α,α-difluoromethylphosphonate as a hydrolytically stable phosphate isostere have been prepared with N-Fmoc protection for use in peptide synthesis. Classes of reagents analogous to both phosphotyrosine and phosphoserine/threonine were prepared by a common route employing a nitrosoarene/aniline condensation to form the azo linkage and the Cu(I)-promoted coupling of an iodoarene with (diethylphosphono)difluoromethyl cadmium bromide (Burton's method) to introduce the phosphonate moiety.
