178313-97-8Relevant articles and documents
Observations on the synthesis of functionalised methyleneaziridines
Ince, Julie,Ross, Tracey M.,Shipman, Michael,Slawin, Alexandra M.Z.,Ennis, David S.
, p. 7037 - 7044 (1996)
N-triphenylmethyl-2-methyleneaziridine 8 was synthesized from N-(2-bromo-2-propenyl)-amine 7 by treatment with sodium amide in liquid ammonia and its structure established using x-ray crystallography. Using modified conditions, (S)-N-(1-phenylethyl)-2-methyleneaziridine 9 was prepared in enantiomerically enriched form. Studies directed towards the synthesis of N-tosyl and N-Boc methyleneaziridines 14 and 15 respectively reveal limitations with this methodology.