178323-47-2

Basic information

• Product Name: 2-Propenoic acid, 3-(4-methoxyphenyl)-3-phenyl-, ethyl ester
• CAS NO: 178323-47-2
• Molecular Formula: C18H18O3
• Molecular Weight: 282.339
• Mol File: 178323-47-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(4-methoxyphenyl)-3-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(4-methoxyphenyl)-3-phenyl-, ethyl ester(178323-47-2)
• EPA Substance Registry System: 2-Propenoic acid, 3-(4-methoxyphenyl)-3-phenyl-, ethyl ester(178323-47-2)

Safety Data

• Hazardous Substances Data: 178323-47-2(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 4192-77-2 ethyl cinnamate 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 696-62-8 para-iodoanisole 
• 63164-96-5 ethyl 4-(2-phenylethynyl)benzoate 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 611-94-9 4-Methoxybenzophenone 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 17684-11-6 3-(4-anisyl)cinnamic acid 
• 178323-59-6 N-tert-butoxycarbonyloxy-N-[3-(4-methoxyphenyl)-3-phenylallyl]carbamic acid tert-butyl ester 
• 178323-48-3 (E)-3-(4-Methoxy-phenyl)-3-phenyl-prop-2-en-1-ol 

Relevant articles and documents

Silver sequestration of halides for the activation of Pd(OAc)2 catalyzed Mizoroki-Heck reaction of 1,1 and 1,2 - Disubstituted alkenes

A ligand free catalytic system consisting of Pd(OAc)2 (cat) and stoichiometric quantities of silver salts, AgOAc or AgBF4, exhibit high efficiency in the Mizoroki-Heck arylation, transforming aryl iodides and 1,1 as well as 1,2 disubstituted alkenes into 1,1,2 – trisubstituted aryl alkenes in excellent yields in very short reaction times.

Palladium-catalyzed hydroarylation of alkynes with arenediazonium salts

The palladium-catalyzed hydroarylation of arenediazonium tetrafluoroborates with alkynes in the presence of triphenylsilane affords stereoselectively hydroarylation products in moderate to high yields. The reaction tolerates a variety of substituents including keto, ester, cyano, and nitro groups and can be performed as a one-pot procedure generating the arenediazonium salt in situ. With ethyl phenylpropynoate as the starting alkyne, the hydroarylation affords ethyl (2)-2-arylcinnamates stereo- and regioselectively.

Tetraphosphine/palladium-catalyzed Heck reactions of aryl halides with disubstituted alkenes

cis,cis,cis-1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/ [PdCl(C3H5)]2 efficiently catalyses the Heck reaction of disubstituted alkenes such as methyl crotonate, ethyl cinnamate, methyl methacrylate or α-methylstyrene with a variety of aryl halides. In the presence of 1,2-disubstituted alkenes the stereoselectivities of the reactions strongly depend on the substituents of the alkenes. Selectivities up to 97% in favor of E-isomers can be obtained for the addition to methyl crotonate. With the 1,1-disubstituted alkenes methyl methacrylate or α-methylstyrene mixtures of products are obtained.