1800300-79-1 Usage
Description
Methyl (2R)-2-amino-3-methoxypropanoate hydrochloride, also known as L-methionine methyl ester hydrochloride, is a chemical compound that serves as a key intermediate in the synthesis of pharmaceuticals and biochemicals. It is the methyl ester of L-methionine, an essential amino acid crucial for protein synthesis and a precursor for the production of other amino acids and vital biomolecules. The hydrochloride salt form of this compound is widely utilized in research and as a laboratory reagent. Characterized by its white to off-white crystalline appearance and solubility in water, it has a molecular weight of 195.65 g/mol. Due to its potential for skin and eye irritation, it is recommended to store this compound in a cool, dry place and handle it with appropriate safety measures.
Uses
Used in Pharmaceutical and Biochemical Synthesis:
Methyl (2R)-2-amino-3-methoxypropanoate hydrochloride is employed as a key intermediate in the synthesis of various pharmaceuticals and biochemicals. Its role in the production of essential amino acids and other biomolecules makes it a valuable component in the development of new drugs and therapeutic agents.
Used in Research and Laboratory Applications:
As a laboratory reagent, methyl (2R)-2-amino-3-methoxypropanoate hydrochloride is used for research purposes, particularly in the study of protein synthesis and the role of L-methionine in biological processes. Its hydrochloride salt form facilitates controlled experiments and analysis in a laboratory setting.
Used in the Production of Amino Acids and Biomolecules:
Methyl (2R)-2-amino-3-methoxypropanoate hydrochloride is utilized in the production of amino acids and important biomolecules, contributing to the development of nutritional supplements, therapeutic agents, and other health-related products.
Used in Drug Delivery Systems:
Innovative drug delivery systems may incorporate methyl (2R)-2-amino-3-methoxypropanoate hydrochloride to enhance the bioavailability and therapeutic efficacy of pharmaceuticals. Its role in these systems can improve the delivery of drugs to target tissues and cells, potentially increasing the effectiveness of treatments.
Used in the Development of Nutritional Supplements:
Given its connection to L-methionine and its involvement in protein synthesis, methyl (2R)-2-amino-3-methoxypropanoate hydrochloride may be used in the development of nutritional supplements designed to support muscle growth, recovery, and overall health.
Used in the Food Industry:
Methyl (2R)-2-amino-3-methoxypropanoate hydrochloride could be utilized in the food industry as a supplement to enhance the nutritional content of products, particularly those aimed at promoting health and well-being through the inclusion of essential amino acids and other beneficial compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1800300-79-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,0,3,0 and 0 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1800300-79:
(9*1)+(8*8)+(7*0)+(6*0)+(5*3)+(4*0)+(3*0)+(2*7)+(1*9)=111
111 % 10 = 1
So 1800300-79-1 is a valid CAS Registry Number.
1800300-79-1Relevant articles and documents
Triazole-containing and cyclic derivative inhibitor Preparation method and application thereof
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Paragraph 0197-0200, (2021/10/27)
The invention relates to a triazolyl-containing and cyclic derivative inhibitor as well as a preparation method and application thereof. , The present invention relates to a compound represented by general formula (I), a preparation method and a pharmaceutical composition thereof, and a use thereof as NK inhibitor in treatment of related diseases such as depression, anxiety, schizophrenia and sex hormone dependence, and the like, wherein each substituent in the general formula (I) is the same as defined in the description.
Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits
Xin, Bo-Tao,Huber, Eva M.,De Bruin, Gerjan,Heinemeyer, Wolfgang,Maurits, Elmer,Espinal, Christofer,Du, Yimeng,Janssens, Marissa,Weyburne, Emily S.,Kisselev, Alexei F.,Florea, Bogdan I.,Driessen, Christoph,Van Der Marel, Gijsbert A.,Groll, Michael,Overkleeft, Herman S.
supporting information, p. 1626 - 1642 (2019/02/19)
Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the β1c, β1i, β5c, and β5i subunits exploit the differences in the substrate-binding channels identified by X-ray crystallography, compounds selectively targeting β2c or β2i could not yet be rationally designed because of the high structural similarity of these two subunits. Here, we report the development, chemical synthesis, and biological screening of a compound library that led to the identification of the β2c- and β2i-selective compounds LU-002c (4; IC50 β2c: 8 nM, IC50 β2i/β2c: 40-fold) and LU-002i (5; IC50 β2i: 220 nM, IC50 β2c/β2i: 45-fold), respectively. Co-crystal structures with β2 humanized yeast proteasomes visualize protein-ligand interactions crucial for subunit specificity. Altogether, organic syntheses, activity-based protein profiling, yeast mutagenesis, and structural biology allowed us to decipher significant differences of β2 substrate-binding channels and to complete the set of subunit-selective proteasome inhibitors.
Preparation method for lacosamide
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Paragraph 0038; 0039, (2017/07/21)
The invention provides a preparation method for lacosamide. According to the invention, easily available Boc-serine (a compound I) is used as a starting material for preparation of lacosamide, and the quality of prepared lacosamide is identical to the quality of an original drug. The preparation method provided by the invention uses easily available raw materials, does not need expensive iodomethane or severely toxic dimethyl sulfate, and is high in product purity and yield and low in toxicity and pollution, and requirements of reaction conditions on equipment are not high; thus, the method is suitable for industrial production.
