862372-14-3

Basic information

• Product Name: methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate
• Synonyms: methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate
• CAS NO: 862372-14-3
• Molecular Weight: 233.265
• Mol File: 862372-14-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate(862372-14-3)
• EPA Substance Registry System: methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate(862372-14-3)

Safety Data

• Hazardous Substances Data: 862372-14-3(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 
• 86123-95-7 (R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid 
• 420-37-1 trimethoxonium tetrafluoroborate 
• 95715-85-8 2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester 
• 4530-20-5 BOC-glycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1800300-79-1 methyl (2R)-2-amino-3-methoxypropanoate hydrochloride 
• 3262-72-4 (R)-N-tert-butoxycarbonyl serine 

Downstream Products

• 721927-59-9 tert-butyl [(2R)-1-hydroxy-3-methoxypropan-2-yl]carbamate 
• 86123-95-7 (R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid 

Relevant articles and documents

Cycloalkyl and heterocycloalkyl inhibitors as well as preparation method and application thereof

The invention relates to cycloalkyl and heterocycloalkyl inhibitors as well as a preparation method and application thereof. Specifically, the compounds disclosed by the invention have a structure as shown in a formula (I). The invention also discloses a preparation method of the compounds and application of the compounds as KRASG12C inhibitors. The compounds have a good selective inhibition effect on KRASG12C, and have better pharmacodynamic and pharmacokinetic properties and lower toxic and side effects.

Preparation method of lacosamide

The invention provides a novel methylation method of a lacosamide synthesis intermediate, which comprises the following steps: methylating a compound I in a reaction solvent at a proper temperature byusing trimethyloxyonium tetrafluoroborate as a methylation reagent under alkaline condition to obtain a methylation product II. The reaction formula is shown in the specification. The method has theadvantages of mild reaction condition, simple post-treatment, green methylation reagent, no high toxicity and high reaction yield, and conforms to the safe and environment-friendly green chemical concept. The method is suitable for laboratory small-scale preparation and large-scale industrial production.

FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF

The present disclosure relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of a Fused Morpholinopyrimidine.