180134-16-1

Basic information

• Product Name: 2-Hydroxy-4,6-bis-trifluoromethyl-benzoic acid
• Synonyms: 2-Hydroxy-4,6-bis-trifluoromethyl-benzoic acid
• CAS NO: 180134-16-1
• Molecular Weight: 274.119
• Mol File: 180134-16-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Hydroxy-4,6-bis-trifluoromethyl-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-4,6-bis-trifluoromethyl-benzoic acid(180134-16-1)
• EPA Substance Registry System: 2-Hydroxy-4,6-bis-trifluoromethyl-benzoic acid(180134-16-1)

Safety Data

• Hazardous Substances Data: 180134-16-1(Hazardous Substances Data)

Upstream product

• 180134-15-0 2,4-Bis(trifluoromethyl)-6-methoxybenzoic acid 
• 349-58-6 3,5-bis-(trifluoromethyl)phenol 
• 349-60-0 1-methoxy-3,5-bis(trifluoromethyl)benzene 
• 46331-50-4 5-methoxyisophthalic acid 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 
• 618-83-7 5-Hydroxyisophthalic acid 
• 20319-44-2 dimethyl 5-methoxyisophthalate 

Relevant articles and documents

2-Methoxy-4,6-bis(trifluoromethyl)phenyllithium: A new stable aryllithium useful as an intermediate to bis(trifluoromethyl)aromatics

A method for the preparation of 3,5-bis(trifluoromethyl)anisole (3) has been developed. Lithiation of 3 occurred exclusively at the position ortho to the CH3O group to give a thermally stable lithium derivative 6 which readily undergoes conventional reactions with a number of electrophiles. Formylation and carboxylation of 6 gave bis(trifluoromethyl) derivatives of salicylic aldehyde and salicylic acid 9-12 in good yields.