46331-50-4

Basic information

• Product Name: 5-METHOXYISOPHTHALIC ACID
• Synonyms: 5-METHOXY-1,3 DICARBOXYLIC ACID;5-METHOXY-ISOPHATHALIC ACID;5-METHOXYISOPHTHALIC ACID;5-Methoxybenzene-1,3-dicarboxylic acid;Nsc302547;5-Methoxy-1,3-benzenedicarboxylic acid;5-Methoxyisophthalic acid 97%
• CAS NO: 46331-50-4
• Molecular Formula: C₉H₈O₅
• Molecular Weight: 196.16
• Product Categories: Organic acids;C9;Carbonyl Compounds;Carboxylic Acids
• Mol File: 46331-50-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 275-280 °C(lit.)
• Boiling Point: 270 °C
• Flash Point: 183.6 °C
• Appearance: /
• Density: 1.416 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO, Methanol
• PKA: 3.41±0.10(Predicted)
• CAS DataBase Reference: 5-METHOXYISOPHTHALIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXYISOPHTHALIC ACID(46331-50-4)
• EPA Substance Registry System: 5-METHOXYISOPHTHALIC ACID(46331-50-4)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 46331-50-4(Hazardous Substances Data)

Usage

Description

5-Methoxyisophthalic acid, also known as MeO-H2ip, is a white solid that is a degradation product of humic acid found in soil. It can be prepared from its dimethyl analog through oxidation in the presence of potassium permanganate in a pyridine-water mixture. This organic compound is known for its potential applications in various industries due to its unique chemical properties.

Uses

Used in Chemical Synthesis:
5-Methoxyisophthalic acid is used as a key intermediate in the synthesis of various organic compounds, including mesophases formed by several homologs of achiral seven-ring bent-core compounds. Its ability to form mesophases makes it a valuable component in the development of new materials with unique properties.
Used in Coordination Chemistry:
In coordination chemistry, 5-Methoxyisophthalic acid is used as a ligand for the synthesis of metal-organic complexes. Some examples of these complexes include [Cd2(MeO-ip)2(bpp)2]n·nH2O and [Ni(MeO-ip)(bpp)(H2O)]n·nH2O, where bpp stands for 1,3-di(4-pyridyl)propane. These complexes exhibit interesting properties and potential applications in areas such as catalysis, magnetism, and luminescence.
Used in Environmental Science:
As a degradation product of humic acid, 5-Methoxyisophthalic acid plays a role in the understanding of soil chemistry and the environmental processes that occur within it. Studying its properties and behavior can provide insights into the formation, degradation, and cycling of organic matter in the soil, which is crucial for sustainable agriculture and environmental management.
Used in Pharmaceutical Research:
The unique chemical structure of 5-Methoxyisophthalic acid may offer potential applications in the pharmaceutical industry, particularly in the development of new drugs or drug delivery systems. Its ability to form complexes with metal ions could be exploited for targeted drug delivery or as a component in the design of novel therapeutic agents.

Upstream product

• 21573-37-5 3-ethyl-5-methyl-anisole 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 
• 618-83-7 5-Hydroxyisophthalic acid 
• 20319-44-2 dimethyl 5-methoxyisophthalate 
• 874-63-5 3,5-dimethylmethoxybenzene 
• 67-71-0 dimethylsulfone 

Downstream Products

• 35227-77-1 4-methoxy-1,3-benzenedicarbonyl dichloride 
• 20319-44-2 dimethyl 5-methoxyisophthalate 
• 113474-24-1 5-methoxy-1,3-cyclohexanedicarboxylic acid 
• 221626-96-6 5-methoxy-N,N'-dipropyl-isophthalamide 
• 180134-13-8 1-Methoxy-2-methyl-3,5-bis-trifluoromethyl-benzene 
• 180134-14-9 2-Methoxy-4,6-bis-trifluoromethyl-benzaldehyde 
• 180134-16-1 2-Hydroxy-4,6-bis-trifluoromethyl-benzoic acid 
• 180134-15-0 2,4-Bis(trifluoromethyl)-6-methoxybenzoic acid 
• 1448179-36-9 [Co(5-methoxyisophthalate)(1,5-bis(imidazol-1-yl)pentane)]_n 
• 108-46-3 recorcinol 
• 90322-75-1 4-Nitro-5-methoxy-isophthalsaeure 
• 349-60-0 1-methoxy-3,5-bis(trifluoromethyl)benzene 

Relevant articles and documents

Highly Selective Carbon Dioxide Capture and Cooperative Catalysis of a Water-Stable Acylamide-Functionalized Metal–Organic Framework

Incorporation of specific functionalities within the framework offers a significant opportunity to produce high-performance gas storage/separation and catalysis MOF materials. In this work, multifunctionalities, including hydrophobic methoxy groups, polar acylamide functionalities, and open copper(II) sites, have been successfully integrated into a twofold interpenetrated microporous MOF (HNUST-6, HNUST represents Hunan University of Science and Technology). HNUST-6 possesses permanent porosity, with a moderate BET surface area of 1093 m2 g–1 and high CO2 adsorption capacity (111 cm3 g–1 at 1 bar), with good selectivity for CO2 over CH4 (6.6) and N2 (30.3) at 273 K. Remarkably, this MOF material exhibits excellent water stability and its framework structure is retained after being immersed in boiling water. In addition, HNUST-6 demonstrates efficient catalytic activity as a cooperative catalyst in a tandem one-pot deacetalization Knoevenagel condensation reaction.

Self-Exfoliated Metal-Organic Nanosheets through Hydrolytic Unfolding of Metal-Organic Polyhedra

Few-layers thick metal-organic nanosheets have been synthesized using water-assisted solid-state transformation through a combined top-down and bottom-up approach. The metal-organic polyhedra (MOPs) convert into metal-organic frameworks (MOFs) which subse

Coordination polymers of ZnII and 5-methoxy isophthalate

Solvothermal reaction of Zn(OAc)2 and 5-methoxy isophthalic acid (H2MeOip) in aqueous alcohols ROH (R = H, Me, Et, or iPr) affords four different novel coordination polymers. Zn2(HMeOip)(MeOip)(OAc) (1) forms as a 1D 'ribbon of rings' polymer. Zn6(MeOip)4.5(HMeOip)(OH)2(H2O)2·5.5H2O (2) crystallises as a complex 3D framework. Zn(MeOip)(H2O)2 H2O (3) is a 1D coordination polymer that contains almost planar strips of Zn(MeOip). compound 4, Zn5(MeOip)4(OH)2(H2O)4·H2O, obtained from aqueous iPrOH, crystallises as a 2D polymer containing two crystallographically distinct Zn5(OH)2 clusters. Preliminary nitric oxide release experiments have been conducted.