180416-31-3

Basic information

• Product Name: N-[5-(10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-ylcarbonyl)pyridin-2-yl]-5-fluoro-2-methylbenzamide
• Synonyms: CL-385004
• CAS NO: 180416-31-3
• Molecular Formula: C₂₆H₂₁FN₄O₂
• Molecular Weight: 440.48127
• Mol File: 180416-31-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[5-(10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-ylcarbonyl)pyridin-2-yl]-5-fluoro-2-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-(10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-ylcarbonyl)pyridin-2-yl]-5-fluoro-2-methylbenzamide(180416-31-3)
• EPA Substance Registry System: N-[5-(10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-ylcarbonyl)pyridin-2-yl]-5-fluoro-2-methylbenzamide(180416-31-3)

Safety Data

• Hazardous Substances Data: 180416-31-3(Hazardous Substances Data)

Upstream product

• 180339-39-3 6-[(5-fluoro-2-methylbenzoyl)amino]pyridine-3-carboxylic acid 
• 180340-68-5 6-[(5-fluoro-2-methylbenzoyl)amino]pyridine-3-carbonyl chloride 
• 201686-63-7 6-[bis-(5-fluoro-2-methyl-benzoyl)-amino]-nicotinic acid ethyl ester 
• 22162-51-2 1-(2-Nitrobenzyl)-2-pyrrolecarboxaldehyde 
• 39658-41-8 ethyl-6-amino-nicotinate 
• 1003-29-8 2-pyrrole aldehyde 
• 22162-53-4 10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine 
• 612-23-7 2-nitrobenzyl chloride 

Relevant articles and documents

5-Fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists

Synthesis and structure-activity relationships (SAR) of orally active arginine vasopressin (AVP) receptor antagonists are discussed. Potent and orally active AVP receptor antagonists are produced when ring A of VPA-985 (1) is replaced with a 3-pyridinyl unit (2b).

TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS

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