1809-14-9Relevant articles and documents
New series of green cyclic ammonium-based room temperature ionic liquids with alkylphosphite-containing anion: Synthesis and physicochemical characterization.
Zarrougui, Ramzi,Raouafi, Noureddine,Lemordant, Daniel
, p. 1193 - 1201 (2014)
A new series of 12 cyclic ammonium-based room temperature ionic liquids (RTILs) containing an alkylphosphite anion have been synthesized by an alkylation reaction between cyclic tertiary amines and dialkylphosphite. This method constitutes an eco-friendly
Lipid-mimicking phosphorus-based glycosidase inactivators as pharmacological chaperones for the treatment of Gaucher's disease
Clarke, Lorne,Overkleeft, Hermen S.,Robinson, Kyle,Santana, Andrés G.,Scherer, Manuel,Withers, Stephen G.,Zhou, Steven
, p. 13909 - 13913 (2021/11/04)
Gaucher's disease, the most prevalent lysosomal storage disorder, is caused by missense mutation of the GBA gene, ultimately resulting in deficient GCase activity, hence the excessive build-up of cellular glucosylceramide. Among different therapeutic strategies, pharmacological chaperoning of mutant GCase represents an attractive approach that relies on small organic molecules acting as protein stabilizers. Herein, we expand upon a new class of transient GCase inactivators based on a reactive 2-deoxy-2-fluoro-β-d-glucoside tethered to an array of lipid-mimicking phosphorus-based aglycones, which not only improve the selectivity and inactivation efficiency, but also the stability of these compounds in aqueous media. This hypothesis was further validated with kinetic and cellular studies confirming restoration of catalytic activity in Gaucher cells after treatment with these pharmacological chaperones.
Method for preparing phosphorus-based extreme pressure anti-wear agent capable of avoiding corrosion or rust formation on metal surface
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Paragraph 0019-0029, (2019/08/26)
The present invention relates to a method for preparing a phosphorus-based extreme pressure anti-wear agent, comprising: mixing phosphorus trichloride and benzene in a reaction bottle with nitrogen gas circulating in the bottle to obtain a reaction mixtur