18103-42-9Relevant articles and documents
Flavonoid glycosides with a triazole moiety for marine antifouling applications: Synthesis and biological activity evaluation
Pereira, Daniela,Gon?alves, Catarina,Martins, Beatriz T.,Palmeira, Andreia,Vasconcelos, Vitor,Pinto, Madalena,Almeida, Joana R.,Correia-Da-silva, Marta,Cidade, Honorina
, (2021/07/28)
Over the last decades, antifouling coatings containing biocidal compounds as active ingre-dients were used to prevent biofouling, and eco-friendly alternatives are needed. Previous research from our group showed that polymethoxylated chalcones and glycosy
Design, synthesis and biological evaluation of flavonoid salicylate derivatives as potential anti-tumor agents
Deng, Xiangping,Wang, Zhe,Liu, Juan,Xiong, Shujuan,Xiong, Runde,Cao, Xuan,Chen, Yanming,Zheng, Xing,Tang, Guotao
, p. 38171 - 38178 (2017/08/16)
A series of flavonoid salicylate derivatives containing trimethoxybenzene and a series of chrysin salicylate derivatives were synthesized for use as anti-tumor agents, and evaluated for antiproliferative activity using three human tumor cells: MCF-7 (breast carcinoma cells), HepG2 (liver carcinoma cells), MGC-803 (gastric carcinoma cells) and the mice tumor cells MFC (forestomach carcinoma cells). A substituent group of a suitable size and the trimethoxybenzene had a certain influence on the bioactivity of the flavonoid salicylate derivatives. Compound 2 and its salicylate derivatives 7a-7g containing the trimethoxybenzene exhibited more antiproliferative activity. Among them, compound 7g displayed the most potent antiproliferative activity against MGC-803 cells and MFC cells with the concentration causing 50% inhibition of cell growth (IC50) values of 11.05 ± 1.58 μM and 13.73 ± 2.04 μM, respectively. The flow cytometry results showed that compound 7g caused the cell cycle to be arrested in the G0/G1 phase and induced apoptosis of MFC cells in a dose-dependent manner. Furthermore, compound 7g showed good anti-tumor activity in vivo. These results suggested that compound 7g could be a new, potent anti-tumor candidate which should be optimized and evaluated further.
Solvent-free synthesis of functionalized flavones under microwave irradiation
Seijas, Julio A.,Vazquez-Tato, M. Pilar,Carballido-Reboredo, Raquel
, p. 2855 - 2858 (2007/10/03)
(Chemical Equation Presented) Eco-friendly direct solvent-free synthesis of flavones is achieved by microwave irradiation of phloroglucinol and β-ketoesters. Heating with microwaves versus under classical conditions was shown to be higher yielding, cleaner, and faster. The reaction goes through a cycloaddition of an α-oxo ketene intermediate followed by an uncatalyzed thermal Fries rearrangement.