53350-26-8

Basic information

• Product Name: 3',4',5',5,7-PENTAMETHOXYFLAVONE
• Synonyms: 5,7,3',4',5'-PENTAMETHOXYFLAVONE;3',4',5',5,7-PENTAMETHOXYFLAVONE;3',4',5,5',7-PENTAMETHOXYFLAVONE;PENTAMETHOXYFLAVONE, 3',4',5',5,7-;TRICIN 5,7,4'-TRIMETHYL ETHER;3',4',5,5',7-PENTAMETHOXYFLAVONE 97%;PENTAMETHOXYFLAVONE, 3',4',5',5,7-(RG);PROTOPANAXADIOL(P)
• CAS NO: 53350-26-8
• Molecular Formula: C₂₀H₂₀O₇
• Molecular Weight: 372.37
• Product Categories: Penta-substituted Flavones;Inhibitors;Tyrosine Kinase Inhibitors;Aromatics;Heterocycles
• Mol File: 53350-26-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 198-200°C
• Boiling Point: 554.4 °C at 760 mmHg
• Flash Point: 243.5 °C
• Appearance: Off-White Crystalline Solid
• Density: 1.244g/cm³
• Solubility: Hot Acetone, Warm Ethanol, Methanol
• CAS DataBase Reference: 3',4',5',5,7-PENTAMETHOXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4',5',5,7-PENTAMETHOXYFLAVONE(53350-26-8)
• EPA Substance Registry System: 3',4',5',5,7-PENTAMETHOXYFLAVONE(53350-26-8)

Safety Data

• Hazardous Substances Data: 53350-26-8(Hazardous Substances Data)

Usage

Description

3',4',5',5,7-PENTAMETHOXYFLAVONE is a naturally occurring flavonoid compound characterized by its off-white crystalline solid appearance. It is known for its unique chemical structure, which includes five methoxy groups at specific positions on the flavone backbone. 3',4',5',5,7-PENTAMETHOXYFLAVONE has garnered interest due to its potential biological activities and applications in various fields.

Uses

Used in Pharmaceutical Industry:
3',4',5',5,7-PENTAMETHOXYFLAVONE is used as a bioactive compound for its potential chemosensitizing effects. It has been found to inhibit ATPase activity, which can enhance the sensitivity of cancer cells to chemotherapy drugs, improving the overall effectiveness of cancer treatment.
Used in Chemical Research:
As a flavonoid, 3',4',5',5,7-PENTAMETHOXYFLAVONE is used as a subject of study in chemical research for its unique properties and potential applications in drug development. Its chemical structure and biological activities make it a valuable compound for further investigation and potential use in the development of new pharmaceuticals.
Used in Nutraceutical Industry:
Due to its natural origin and potential health benefits, 3',4',5',5,7-PENTAMETHOXYFLAVONE may be used as an ingredient in the nutraceutical industry. It could be incorporated into dietary supplements or functional foods for its potential health-promoting properties.

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 53350-27-9 (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 18103-42-9 5,7-dihydroxy-3',4',5'-trimethoxyflavone 
• 1719-88-6 3,4,5-trimethoxybenzoic anhydride 
• 392302-43-1 acetic acid 2-[2,3-dibromo-3-(3,4,5-trimethoxy-phenyl)-propionyl]-3,5-dimethoxy-phenyl ester 
• 54987-78-9 2'-acetoxy-3,4,5,4',6'-pentamethoxy-chalcone 
• 108-73-6 3,5-dihydroxyphenol 
• 392302-51-1 Acetic acid 2-[(Z)-2-bromo-3-(3,4,5-trimethoxy-phenyl)-acryloyl]-3,5-dimethoxy-phenyl ester 
• 121817-16-1 2-acetyl-3,5-dimethoxyphenyl-3,4,5-trimethoxyphenyl ester 
• 3755-71-3 5,7-diacetoxy-2-(4-acetoxy-3,5-dimethoxy-phenyl)-chromen-4-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 118-41-2 Eudesmic acid 
• 18103-41-8 5-hydroxy-7-methoxy-2-(3',4',5'-trimethoxyphenyl)-4H-chromen-4-one 
• 190323-49-0 3-hydroxy-5,7-dimethoxy-2–(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 
• 520-31-0 tricetin 

Relevant articles and documents

Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors

The biological effects of flavonoids on mammal cells are diverse, ranging from scavenging free radicals and anti-cancer activity to anti-influenza activity. Despite appreciable effort to understand the anti-influenza activity of flavonoids, there is no clear consensus about their precise mode-of-action at a cellular level. Here, we report the development and validation of a screening assay based on AlphaScreen technology and illustrate its application for determination of the inhibitory potency of a large set of polyols against PA N-terminal domain (PA-Nter) of influenza RNA-dependent RNA polymerase featuring endonuclease activity. The most potent inhibitors we identified were luteolin with an IC50 of 72 ± 2 nM and its 8-C-glucoside orientin with an IC50 of 43 ± 2 nM. Submicromolar inhibitors were also evaluated by an in vitro endonuclease activity assay using single-stranded DNA, and the results were in full agreement with data from the competitive AlphaScreen assay. Using X-ray crystallography, we analyzed structures of the PA-Nter in complex with luteolin at 2.0 ? resolution and quambalarine B at 2.5 ? resolution, which clearly revealed the binding pose of these polyols coordinated to two manganese ions in the endonuclease active site. Using two distinct assays along with the structural work, we have presumably identified and characterized the molecular mode-of-action of flavonoids in influenza-infected cells.

Synthesis and Antiproliferative Activity of Natural and Non-Natural Polymethoxychalcones and Polymethoxyflavones

Two series of polymethoxychalcones and polymethoxyflavones, including the natural products 2′-hydroxy-3,4,5,4′,6′-pentamethoxychalcone (8c), 5,6,7,8,3′,4′,5′-heptamethoxyflavone (6), 5,7,3′,4′,5′-pentamethoxyflavone (9c), 3-hydroxy-5,6,7,8,3′,4′,5′-heptam

Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs

Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.