18159-24-5

Basic information

• Product Name: 1-(PHENYLMETHYL)-1H-PYRROLE-2-CARBOXALDEHYDE
• Synonyms: 1-(PHENYLMETHYL)-1H-PYRROLE-2-CARBOXALDEHYDE;1-BENZYL-1H-PYRROLE-2-CARBALDEHYDE;1H-PYRROLE-2-CARBOXALDEHYDE, 1-(PHENYLMETHYL)-
• CAS NO: 18159-24-5
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22
• Mol File: 18159-24-5.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 123-125 °C(Press: 1.1 Torr)
• Appearance: /
• Density: 1.04±0.1 g/cm3(Predicted)
• PKA: -6.98±0.70(Predicted)
• CAS DataBase Reference: 1-(PHENYLMETHYL)-1H-PYRROLE-2-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(PHENYLMETHYL)-1H-PYRROLE-2-CARBOXALDEHYDE(18159-24-5)
• EPA Substance Registry System: 1-(PHENYLMETHYL)-1H-PYRROLE-2-CARBOXALDEHYDE(18159-24-5)

Safety Data

• Hazardous Substances Data: 18159-24-5(Hazardous Substances Data)

Usage

Physical state

Yellow solid

Odor

Faint, sweet, floral

Uses

a. Production of pharmaceuticals
b. Production of fine chemicals

Properties

a. Antimicrobial
b. Antifungal

Safety precautions

a. Potential skin irritation
b. Potential eye irritation
c. Potential respiratory irritation
d. Safe handling and storage
e. Safe disposal to prevent environmental contamination

Upstream product

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• 1003-29-8 2-pyrrole aldehyde 
• 56-37-1 N-benzyl-N,N,N-triethylammonium chloride 
• 53912-80-4 (S)-N-benzylprolinol 
• 56454-01-4 1-benzyl-2-chloro-1H-pyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 156210-70-7 1-benzyl-2-methylthiopyrrole-5-carboxaldehyde 
• 100-44-7 benzyl chloride 
• 90724-50-8 5-methylthio-1H-pyrrole-2-carboxaldehyde 
• 1007389-00-5 (1-benzyl-1H-pyrrol-2-yl)methanol 
• 156210-65-0 1-benzyl-2-methylsulfonylpyrrole-5-carboxaldehyde 
• 156210-54-7 1-(2-bromobenzyl)-1H-pyrrole-2-carbaldehyde 

Downstream Products

• 60290-15-5 (2E)-3-(1-benzyl-1H-pyrrol-2-yl)acryloyl azide 
• 942066-87-7 6-[1-(phenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester 
• 868616-86-8 6-[1-(phenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid 
• 1410884-83-1 (E)-1-benzyl-N-(tert-butyl)-6-cyclohexyl-4-ethylidene-5-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide 
• 1410885-02-7 1-benzyl-N-(tert-butyl)-7-cyclohexyl-4-methyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide 
• 922174-11-6 C₁₂H₁₀INO 
• 78075-83-9 1-benzyl-2-methyl-1H-pyrrole 
• 79407-68-4 3-(1-Benzyl-1H-pyrrol-2-yl)-5,6,9-trimethoxy-3H-phenanthro[9,10-c]furan-1-one 
• 132205-81-3 trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene 
• 87177-13-7 3-(1-Benzyl-1H-pyrrol-2-yl)-3H-naphtho[1,2-c]furan-1-one 
• 87166-84-5 3-(1-Benzyl-1H-pyrrol-2-yl)-3H-isobenzofuran-1-one 
• 1963-42-4 2-(p-methoxybenzyl)pyrrole 

Relevant articles and documents

Magnetic sulfonated polysaccharides as efficient catalysts for synthesis of isoxazole-5-one derivatives possessing a substituted pyrrole ring, as anti-cancer agents

Four polysaccharides (chitosan, cellulose, starch, and pectin) were magnetized with magnetic iron oxide (Fe3O4) and then sulfonated (except pectin) with chlorosulfonic acid. The obtained solid acids were used as a catalyst in three-component reactions bet

N-Heterocyclic Carbene Catalyzed Deuteration of Aldehydes in D 2 O

An N-heterocyclic carbene (NHC)-catalyzed direct deuteration of aldehydes in a mixed solvent of deuterium oxide (D 2 O) and cyclopentyl methyl ether was established. The present deuteration is possibly initiated by the formation of a Breslow intermediate from the aldehyde and the NHC, with subsequent trapping by D 2 O providing the monodeuterated aldehyde.

Serendipitous base catalysed condensation-heteroannulation of iminoesters: a regioselective route to the synthesis of 4,6-disubstituted 5-azaindoles

A serendipitous discovery of a novel one-pot synthesis of 4,6-disubstituted 5-azaindoles is reported herein. In the presence of Hunig's base, various N-substituted pyrrole-2-carboxaldehydes have been efficiently transformed into their corresponding 4,6-disubstituted 5-azaindoles through an imine mediated cascade condensation-heteroannulation. The synthetic value of the methodology is established by preparing a novel chemical analogue of a cannabinoid receptor type 2 (CB2) agonist.