182438-97-7Relevant articles and documents
PROCESS FOR THE PREPARATION OF LOMITAPIDE
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Page/Page column 15, (2016/06/01)
The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.
Method for synthesizing triglyceride transfer protease inhibitor
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Paragraph 0031; 0032; 0033; 0034, (2016/12/26)
The invention discloses a method for synthesizing the triglyceride transfer protease inhibitor Lomitapide. Specifically, based on improvement of an existing technique, the compounds 9-carboxyfluorene and 1,4-dibromobutane are used as raw materials, five-step reaction is conducted, and the defects of the prior art are overcome. Compared with the prior art, the method has the main advantage that column chromatography purification is avoided, and product purification is conducted with a recrystallization method which is economical and environment-friendly.
5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP
Sulsky, Richard,Robl, Jeffrey A.,Biller, Scott A.,Harrity, Thomas W.,Wetterau, John,Connolly, Fergal,Jolibois, Kern,Kunselman, Lori
, p. 5067 - 5070 (2007/10/03)
5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2- dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.