183438-24-6

Basic information

• Product Name: 5-Bromo-2-iodopyrimidine
• Synonyms: 5-BROMO-2-IODOPYRIMIDINE;5-Bromo-iodopyrimidine;5-Brmo-2-iodopyrimidine;5-bromo-2-iodopyrimine;2-broMo-5-iodopyriMidine;5-BroMo-2-iodopyriMidine (This product is unavailable in the U.S.);5-Bromo-2-iodo-1,3-diazine;5-BroMo-2-iodopyriMidine
• CAS NO: 183438-24-6
• Molecular Formula: C₄H₂BrIN₂
• Molecular Weight: 284.88
• EINECS: 1312995-182-4
• Product Categories: Pyrimidine Series;Halides;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Pyrazines, Pyrimidines & Pyridazines;Pyrimidine;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 183438-24-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 99-103 °C(lit.)
• Boiling Point: 341 °C at 760 mmHg
• Flash Point: 160 °C
• Appearance: White to tan/Crystalline Powder
• Density: 2.495 g/cm³
• Vapor Pressure: 0.000164mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -2.56±0.22(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-Bromo-2-iodopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-iodopyrimidine(183438-24-6)
• EPA Substance Registry System: 5-Bromo-2-iodopyrimidine(183438-24-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/38-36/37/38
• Safety Statements: 26-37/39-37
• WGK Germany: 3
• HazardClass: IRRITANT, LIGHT SENSITIVE
• Hazardous Substances Data: 183438-24-6(Hazardous Substances Data)

Usage

Description

5-Bromo-2-iodopyrimidine is a white solid chemical compound that can be synthesized by reacting 5-bromo-2-chloropyrimidine with hydroiodic acid. It is a halogenated pyrimidine derivative, which is a type of heterocyclic organic compound with potential applications in various fields.

Uses

Used in Organic Synthesis:
5-Bromo-2-iodopyrimidine is used as a key intermediate in the synthesis of various organic compounds, such as 5,5′-dibromo-2,2′-bipyrimidine and O,O′-dimethyl hyrtinadine A. Its unique structure and reactivity make it a valuable building block for the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Bromo-2-iodopyrimidine is used as a starting material for the synthesis of novel therapeutic agents. Its halogenated pyrimidine structure can be further modified and functionalized to create new drug candidates with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Used in Agrochemical Industry:
5-Bromo-2-iodopyrimidine can also be utilized in the agrochemical industry for the development of new pesticides and herbicides. Its chemical properties and reactivity allow for the creation of new active ingredients with improved efficacy, selectivity, and environmental compatibility.
Used in Research and Development:
In the field of research and development, 5-Bromo-2-iodopyrimidine serves as a valuable tool for studying the structure-activity relationships of pyrimidine-based compounds. It can be used to investigate the effects of halogenation on the biological activity and physicochemical properties of pyrimidines, providing insights into the design of new and improved pyrimidine-containing molecules.

InChI:InChI=1/C4H2BrIN2/c5-3-1-7-4(6)8-2-3/h1-2H

Upstream product

• 38353-09-2 2-pyrimidinone hydrochloride 
• 7752-82-1 5-bromo-2-aminopyrimidine 
• 38353-09-2 2-hydroxypyrimidine hydrochloride 
• 32779-36-5 5-Bromo-2-chloropyrimidine 

Downstream Products

• 183437-80-1 5-bromo-2-(4-(trifluoromethyl)phenyl)pyrimidine 
• 155802-47-4 2-(4'-Octyloxyphenyl)-5-bromopyrimidine 
• 909849-04-3 5-bromo-2-[4-(trifluoromethoxy)phenyl]pyrimidine 
• 854935-06-1 3-{4-[(5-bromopyrimidin-2-yl)oxy]phenoxy}quinuclidine 
• 927805-70-7 2-(5-bromopyrimidin-2-yl)-3-(tert-butyldiphenylsilyloxy)furo[2,3-c]pyridine 
• 883901-68-6 5-bromo-2-vinyl-pyrimidine 
• 38275-58-0 pyrimidine-2,5-dicarbonitrile 
• 167018-88-4 2-(2',3'-difluoro-4'-octyloxyphenyl)-5-bromopyrimidine 
• 289-95-2 PYRIMIDINE 
• 152915-90-7 5-bromo-2-[4-(phenylmethoxy)phenyl]-pyrimidine 
• 183437-82-3 2-(3',4'-Difluorophenyl)-5-bromopyrimidine 
• 521268-34-8 (2S)-1-({2-[5-(4-Cyano-phenyl)-pyrimidin-2-ylamino]-1,1-dimethyl-ethylamino}-acetyl)-pyrrolidine-2-carbonitrile 
• 521268-33-7 (2S)-1-({2-[5-(3-Cyano-phenyl)-pyrimidin-2-ylamino]-1,1-dimethyl-ethylamino}-acetyl)-pyrrolidine-2-carbonitrile 
• 521268-31-5 (2S)-1-{[1,1-Dimethyl-2-(5-phenyl-pyrimidin-2-ylamino)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile 

Relevant articles and documents

The synthesis and characterisation of novel thienyl-pyrimidine liquid crystalline materials

The synthesis and transition temperatures of a series of novel thienyl-pyrimidine liquid crystalline materials is described. Palladium catalysed coupling of 5-n-alkyl-2-tri-n-butylstannyl thiophenes to 5-bromo-2-iodopyrimidine is used to create novel pyrimidine compounds which exhibit lower melting points than similar pyrimidine liquid crystals. These compounds exhibit a variety of phases including smectic A, C, G, B and hexstatic B also they exhibit several as yet unidentifiable phases. Speculation as to hydrogen bonding in the liquid crystalline core is also discussed therein.

ORGANIC COMPOUNDS, ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTID DEVICE HAVING THE COMPOUNDS

The present invention relates to an organic compound in which a bipyrimidine moiety serving as an electron acceptor is connected via an aromatic linker to a hetero-aromatic moiety serving as an electron donor and containing one to two nitrogen atoms. The organic compound, since it contains both electron donor and electron acceptor moieties in a single molecule, allows electric charges to move easily, thereby increasing luminance efficiency. Also, since the electron donor is made of solid condensed aromatic rings, such as carbazole, acridine, or indole rings, the 3D structure of the molecule is hindered. Thus, the organic compound of the present invention may be used as a delayed fluorescence dopant emitting a blue light of high chromatic purity. The organic compound of the present invention may be applied to organic light-emitting devices, such as an organic light-emitting diode, a display device, and a lighting device, to lower the driving voltage thereof while increasing luminance efficiency and chromatic purity thereof.COPYRIGHT KIPO 2019

TRICYCLIC GYRASE INHIBITORS FOR USE AS ANTIBACTERIAL AGENTS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

TRICYCLIC GYRASE INHIBITORS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.