18354-39-7

Basic information

• Product Name: 4-methoxy-N-(phenylcarbamoyl)benzamide
• CAS NO: 18354-39-7
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.2833
• Mol File: 18354-39-7.mol
• Article Data: 4

Chemical Properties

• Density: 1.258g/cm³
• Refractive Index: 1.623
• CAS DataBase Reference: 4-methoxy-N-(phenylcarbamoyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N-(phenylcarbamoyl)benzamide(18354-39-7)
• EPA Substance Registry System: 4-methoxy-N-(phenylcarbamoyl)benzamide(18354-39-7)

Safety Data

• Hazardous Substances Data: 18354-39-7(Hazardous Substances Data)

Usage

General Description

4-methoxy-N-(phenylcarbamoyl)benzamide, also known as moclobemide, is a pharmaceutical compound used as an antidepressant and anxiolytic medication. It belongs to the class of reversible monoamine oxidase inhibitors (MAOIs) and works by blocking the action of the enzyme monoamine oxidase, which in turn increases the levels of neurotransmitters such as serotonin, dopamine, and norepinephrine in the brain. This increase in neurotransmitter levels is thought to be responsible for the antidepressant and anxiolytic effects of moclobemide. The compound is usually administered as a tablet and has been found to be effective in the treatment of major depressive disorder and social anxiety disorder. However, as with all medications, it may have potential side effects and should be used under the guidance of a healthcare professional.

Upstream product

• 917-61-3 sodium isocyanate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 62-53-3 aniline 
• 201230-82-2 carbon monoxide 
• 3532-17-0 4-methoxybenzoyl azide 
• 696-62-8 para-iodoanisole 
• 64-10-8 phenyl carbamate 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 3424-93-9 4-methoxyphenylacetamide 
• 104825-42-5 1,1-Bis-(4-methoxy-benzoyl)-3,3-dimethyl-urea 
• 4695-57-2 4-methoxybenzoyl isocyanate 

Relevant articles and documents

Pd-Catalyzed Carbonylation of Acyl Azides

Pd-catalyzed reactions of azides with CO to access an isocynate intermediate have been developed extensively in recent years. However, the catalytic carbonylation of sensitive acyl azides has not been reported. Herein, we report a simple Pd-catalyzed carbonylation reaction of acyl azides with broad substrate scope, high efficiency, and simple operation under mild conditions, which provides facile access to acyl ureas. In addition, a mechanistic study was carried out by both experiment and DFT calculation. Control experiments and kinetic study revealed that the real active palladium species were Pd(0). The result of kinetic study suggested that palladium catalyst, azide, and CO were all involved in the turnover-limiting step except for amine. Further DFT study suggested that an unprecedented five-membered palladacycle intermediate was the key intermediate in the carbonylation reaction. ?

CONDENSATION OF ACYL CHLORIDE ON SODIUM CYANATE : PREPARATION OF ACYL ISOCYANATES

The catalytic effects of various metal halides and solvents on the reaction of benzoyl chloride with sodium cyanate were studied.It has been found that SnCl4, and ZnCl2 catalyze the reaction to give the corresponding acyl isocyanates in good yields.The scope of the reaction was studied and a number of aroyl isocyanates and their derivatives were prepared.A few non aromatic isocyanates and their derivatives were also prepared.