183890-34-8

Basic information

• Product Name: 2-Piperidinecarboxylicacid,6-oxo-,methylester,(2R)-(9CI)
• Synonyms: 2-Piperidinecarboxylicacid,6-oxo-,methylester,(2R)-(9CI);(R)-Methyl 6-oxopiperidine-2-carboxylate;(2R)-6-Oxo-2-piperidinecarboxylic acid methyl ester;(R)-6-oxo-2-Piperidinecarboxylic acid methyl ester
• CAS NO: 183890-34-8
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.17
• Product Categories: CARBOXYLICESTER
• Mol File: 183890-34-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 316℃
• Flash Point: 145℃
• Appearance: /
• Density: 1.150
• CAS DataBase Reference: 2-Piperidinecarboxylicacid,6-oxo-,methylester,(2R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarboxylicacid,6-oxo-,methylester,(2R)-(9CI)(183890-34-8)
• EPA Substance Registry System: 2-Piperidinecarboxylicacid,6-oxo-,methylester,(2R)-(9CI)(183890-34-8)

Safety Data

• Hazardous Substances Data: 183890-34-8(Hazardous Substances Data)

Upstream product

• 72002-30-3 (R)-6-oxo-piperidine-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 7620-28-2 D-2-aminoadipic acid 
• 183890-36-0 (R)-6-oxopiperidine-1,2-dicarboxylic acid 1-tertiary butyl ester 2-methyl ester 
• 97347-42-7 (R)-2,6-Bis-tert-butoxycarbonylamino-6-oxo-hexanoic acid methyl ester 

Downstream Products

• 213532-95-7 (R)-6-hydroxymethyl-piperidin-2-one 

Relevant articles and documents

Interrupted Pyridine Hydrogenation: Asymmetric Synthesis of δ-Lactams

Metal-catalyzed hydrogenation is an effective method to transform readily available arenes into saturated motifs, however, current hydrogenation strategies are limited to the formation of C?H and N?H bonds. The stepwise addition of hydrogen yields reactive unsaturated intermediates that are rapidly reduced. In contrast, the interruption of complete hydrogenation by further functionalization of unsaturated intermediates offers great potential for increasing chemical complexity in a single reaction step. Overcoming the tenet of full reduction in arene hydrogenation has been seldom demonstrated. In this work we report the synthesis of sought-after, enantioenriched δ-lactams from oxazolidinone-substituted pyridines and water by an interrupted hydrogenation mechanism.

EP4 receptor agonist, compositions and methods thereof

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

EP4 receptor agonist, compositions and methods thereof

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.