18441-43-5

Basic information

• Product Name: 5-methylbenzofuran
• Synonyms: 5-methylbenzofuran;Einecs 242-318-4;Benzofuran, 5-Methyl-;5-Methylbenzo[b]furan;5-methyl-1-benzofuran
• CAS NO: 18441-43-5
• Molecular Formula: C₉H₈O
• Molecular Weight: 132.15922
• EINECS: 242-318-4
• Mol File: 18441-43-5.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 198°C (estimate)
• Flash Point: 89.4°C
• Appearance: /
• Density: 1.0603
• Vapor Pressure: 0.569mmHg at 25°C
• Refractive Index: 1.5570
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-methylbenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methylbenzofuran(18441-43-5)
• EPA Substance Registry System: 5-methylbenzofuran(18441-43-5)

Safety Data

• Hazardous Substances Data: 18441-43-5(Hazardous Substances Data)

Usage

General Description

5-Methylbenzofuran, also known as 5-MBF or 1-benzofuran-5-methanol, is an organic compound with the chemical formula C9H8O. It is a benzofuran derivative with a methyl group attached to the fifth position of the benzene ring. 5-Methylbenzofuran is primarily used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds. It possesses potential therapeutic properties and has been studied for its antifungal and anti-inflammatory activities. Additionally, 5-MBF has shown promise in the development of new drugs for the treatment of neurological disorders and cancer. Nevertheless, it is important to handle 5-methylbenzofuran with caution due to its potential health hazards, including irritation to the skin, eyes, and respiratory system, as well as its flamability.

InChI:InChI=1/C9H8O/c1-7-2-3-9-8(6-7)4-5-10-9/h2-6H,1H3

Upstream product

• 66614-56-0 1-(2,2-diethoxyethoxy)-4-methylbenzene 
• 51673-84-8 dimethoxyacetaldehyde 
• 17429-02-6 4-hydroxy-4-methylcyclohexanone 
• 106-44-5 p-cresol 
• 865759-98-4 2-allyl-1-(2-chloroethoxy)-4-methylbenzene 
• 23431-48-3 allyl p-tolyl ether 
• 609-39-2 2-nitrofuran 
• 78-79-5 isoprene 
• 121836-00-8 2-<2-hydroxy-1-(isopropylthio)ethyl>-p-cresol 
• 88521-64-6 2-formyl-4-methylphenoxyacetic acid 
• 6628-06-4 2-allyl-4-methylphenol 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 88521-73-7 ethyl 2-(2-formyl-4-methylphenoxy)acetate 

Downstream Products

• 1027468-03-6 3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isobutyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 145824-23-3 ethyl 1-[[2-(2-aminophenyl)-3-bromo-5-benzofuranyl]methyl]-4-chloro-2-propyl-1H-imidazole-5-carboxylate 
• 146650-66-0 {2-[3-Bromo-5-(2-ethyl-5-formyl-4-methyl-imidazol-1-ylmethyl)-benzofuran-2-yl]-phenyl}-carbamic acid tert-butyl ester 
• 146650-73-9 ethyl 1-[[3-bromo-2-(2-aminophenyl)-5-benzofuranyl]methyl]-4-chloro-2-ethyl-1H-imidazole-5-carboxylate 
• 1026340-43-1 3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-isopropyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 146650-75-1 3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2,5-diethyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 146650-91-1 ethyl 1-[[2-(2-aminophenyl)-3-bromo-5-benzofuranyl]methyl]-4-methyl-2-propyl-1H-imidazole-5-carboxylate 
• 146650-74-0 3-[2-(2-Amino-phenyl)-3-bromo-benzofuran-5-ylmethyl]-2-ethyl-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 1027957-17-0 Ethyl 1-[[3-bromo-2-(2-aminophenyl)-5-benzofuranyl]methyl]-2,4-dimethyl-1H-imidazole-5-carboxylate 
• 146624-98-8 [2-(5-Bromomethyl-3-chloro-benzofuran-2-yl)-phenyl]-carbamic acid tert-butyl ester 
• 145824-11-9 1,1-dimethylethyl <2-(3-bromo-5-(bromomethyl)-2-benzofuranyl)phenyl>carbamate 
• 146014-01-9 1,1-dimethylethyl 2-<3-bromo-5-(bromomethyl)-2-benzofuranyl>benzoate 
• 146624-44-4 1,1-dimethylethyl <2-(3-bromo-5-methyl-2-benzofuranyl)phenyl>carbamate 
• 146624-97-7 [2-(3-Chloro-5-methyl-benzofuran-2-yl)-phenyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis

We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION

Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.

Dioxazolones as masked ester surrogates in the Pd(ii)-catalyzed direct C-H arylation of 6,5-fused heterocycles

A simple and effective Pd(ii)-catalyzed regioselective C(2)-H arylation of 6,5-fused heterocycles with dioxazolones as a masked ester surrogate under mild conditions is reported. The significance of the arylation is highlighted by the new reactivity demonstrated in dioxazolones via proximal C-H activation of the cyclic carbonate of the hydroxamic acid functionality under protic conditions.