18458-71-4Relevant articles and documents
Synthesis and anticancer activities of novel guanylhydrazone and aminoguanidine tetrahydropyran derivatives
Silva, Fábio Pedrosa Lins,Dantas, Bruna Braga,Martins, Gláucia Veríssimo Faheina,De Araújo, Demétrius Ant?nio Machado,Vasconcellos, Mário Luiz Araújo De Almeida
, (2016/07/06)
In this paper we present the convenient syntheses of six new guanylhydrazone and aminoguanidine tetrahydropyran derivatives 2-7. The guanylhydrazone 2, 3 and 4 were prepared in 100% yield, starting from corresponding aromatic ketones 8a-c and aminoguanidi
Diastereoselective syntheses via Prins cyclization, crystal structures determination and theoretical studies of cis-2,6-diphenyl-4- hydroxytetrahydropyran and analogues
Silva,Sabino,Martins,Vasconcellos
, p. 478 - 487 (2013/03/29)
We report in this article the diastereoselective syntheses of tetrahydropyranyl derivatives 1-5, its cis configurational ascertainment by spectroscopy and finally the crystal structures determination that unequivocally shows the 1-5 configurations and its
Carbonyl umpolung reactivity of enals: NHC-catalyzed synthesis of aldol products via epoxide ring opening
Yadav, Lal Dhar S.,Singh, Santosh,Rai, Vijai K.
experimental part, p. 240 - 246 (2010/04/02)
A novel one-pot N-heterocyclic carbene catalyzed synthesis of aldol products and their application to a facile and highly cis-selective synthesis of tetrahydropyran-4-ones is reported. The protocol involves carbonyl umpolung reactivity of enals in which the carbonyl carbon attacks nucleophilically on electrophilic terminal epoxides, regioselectively, to afford aldol adducts in good to excellent yields. Georg Thieme Verlag Stuttgart - New York.