53063-63-1Relevant articles and documents
Diastereoselective Synthesis of Highly Substituted Tetrahydropyran-4-ones
Clarke, Paul A.,Martin, William H. C.
, p. 4527 - 4529 (2002)
(Matrix Presented) Aldol reactions of β-ketoesters with aldehydes followed by a tandem Knoevenagel condensation, with a further equivalent of aldehyde, and intramolecular Michael addition produces single diastereomers of highly substituted tetrahydropyran-4-ones.
Investigation of the mechanism for the preparation of 6-phenyl-2,4- dioxotetrahydropyrans by the potassium carbonate promoted condensation between acetoacetate esters and benzaldehyde
Andersh, Brad,Nguyen, Elizabeth T.,Van Hoveln, Ryan J.,Kemmerer, Dylan K.,Baudo, David A.,Graves, Jessica A.,Roark, Mollie E.,Bosma, Wayne B.
, p. 4563 - 4567 (2013/06/05)
Treatment of benzaldehyde and an acetoacetate ester with potassium carbonate in an alcohol solvent proceeds via γ-C-alkylation rather than α-C-alkylation resulting in the formation of 6-phenyl-2,4- dioxotetrahydropyran. Based upon results from deuterium e
A short and convenient strategy for the synthesis of pyridazines via Diaza-Wittig reaction
Bel Abed, Hassen,Mammoliti, Oscar,Van Lommen, Guy,Herdewijn, Piet
supporting information, p. 6489 - 6491 (2013/01/15)
A convenient and selective synthesis of 6-substituted-4-hydroxy-3- methoxycarbonyl pyridazines has been developed via a diaza-Wittig reaction. The desired products substituted at the C6 position can be obtained from readily available starting materials under mild conditions. This represents an attractive new method for the synthesis of pyridazine derivatives.
Biomimetic synthesis of hyperolactones
Wu, Yingying,Du, Chao,Hu, Congcong,Li, Ying,Xie, Zhixiang
supporting information; experimental part, p. 4075 - 4081 (2011/06/26)
Through a biomimetic pathway, hyperolactone D, 4-hydroxyhyperolactone D, and hyperolactone C were synthesized from methyl acetoacetate via Weilers dianion method, asymmetric allylic alkylation, biomimetic lactonization, oxidation, and cyclization. The stereochemistry of the quaternary carbon was controlled efficiently by Palladium-catalyzed asymmetric allylic alkylation. This strategy was also used for the synthesis of hyperolactone B.