185384-15-0

Basic information

• Product Name: Carbamic acid, [(1S)-1-(bromomethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester
• CAS NO: 185384-15-0
• Molecular Formula: C14H20BrNO2
• Molecular Weight: 314.222
• Mol File: 185384-15-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-(bromomethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-(bromomethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester(185384-15-0)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-(bromomethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester(185384-15-0)

Safety Data

• Hazardous Substances Data: 185384-15-0(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 3182-95-4 L-Phenylalaninol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 126301-19-7 (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 

Downstream Products

• 190589-80-1 3,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propoxy)-benzoic acid methyl ester 
• 134557-74-7 tert-butyl [(2S)-1-azido-3-phenylpropan-2-yl]carbamate 
• 109687-70-9 tert-butyl (S)-(1-phenyl-3-(phenylthio)propan-2-yl)carbamate 
• 891202-50-9 tert-butyl (S)-(1-phenyl-3-(phenylselanyl)propan-2-yl)carbamate 
• 1032818-17-9 C₁₉H₃₀N₂O₃ 
• 185384-17-2 [(S)-1-Benzyl-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyl]-carbamic acid tert-butyl ester 
• 790627-88-2 (S)-N¹-((S)-2-Amino-3-phenyl-propyl)-3-phenyl-propane-1,2-diamine 
• 146552-72-9 (S)-2-(t-butoxycarbonylamino)-3-phenylpropylamine 
• 190589-82-3 3,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propoxy)-benzoic acid 

Relevant articles and documents

N-bromosuccinimide promoted synthesis of β-amino bromides under Appel reaction condition

An efficient and facile method has been developed for the synthesis of chiral β-amino bromides from their corresponding alcohols under Appel reaction conditions. This approach allows for the deoxybromination of a variety of β-amino alcohols in excellent y

A method for preparing may compared to the department he intermediate and intermediate thereof and use thereof

The invention relates to the field of medicinal chemical synthesis, in particular to a cobicistat intermediate preparing method, an intermediate and application thereof. The cobicistat intermediate (a compound (4)) preparing method includes the steps that a compound (5) is prepared into an organic metal compound (5'), and the compound (5') reacts with a compound (6) to prepare the compound (4) (see the reaction process in the description). The new reaction raw material compound (5) or (6) is provided to obtain the new compound (4) preparing method, the overall yield of the reaction can be increased, usage of toxic reagents is avoided, side reactions are reduced, and the cobicistat intermediate preparing method is suitable for industrial production. Further, the compound (4) is used as the intermediate for preparing a compound (1), by-products in the prior art are avoided, usage of toxic reagents is avoided, cost is saved, and the intermediate is beneficial for environment maintenance and suitable for industrial production.

Convergent synthesis and diversity of amino acid based dendrimers

The synthesis of amino acid based dendrimers 25 (fifth generation, 32 endgroups), 30 (fourth generation, 81 endgroups), chiral dendrimer 23 (third generation, 8 endgroups) as well as core-modified dendrimers 34 and 38 by the convergent method is described. The amino acid building blocks are derived from hydroxybenzoic acid derivatives and amino alcohol derivatives, and access to a considerable molecular diversity of these novel dendrimers can be achieved, The synthesis can be carried out on a relatively large scale, and this easy access of the dendrimers may lead to many potential applications.