186312-71-0

Basic information

• Product Name: 5-[2,4-Dioxo-thiazolidin-(5E)-ylidenemethyl]-2-methoxy-benzoic acid methyl ester
• Synonyms: 5-[2,4-Dioxo-thiazolidin-(5E)-ylidenemethyl]-2-methoxy-benzoic acid methyl ester
• CAS NO: 186312-71-0
• Molecular Weight: 293.3
• Mol File: 186312-71-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[2,4-Dioxo-thiazolidin-(5E)-ylidenemethyl]-2-methoxy-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2,4-Dioxo-thiazolidin-(5E)-ylidenemethyl]-2-methoxy-benzoic acid methyl ester(186312-71-0)
• EPA Substance Registry System: 5-[2,4-Dioxo-thiazolidin-(5E)-ylidenemethyl]-2-methoxy-benzoic acid methyl ester(186312-71-0)

Safety Data

• Hazardous Substances Data: 186312-71-0(Hazardous Substances Data)

Upstream product

• 2295-31-0 thiazoline-2,4-dione 
• 78515-16-9 methyl 5-formyl-2-methoxybenzoate 

Downstream Products

• 185808-44-0 N-(3,5-bis-trifluoromethyl-benzyl)-5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-benzamide 
• 186312-77-6 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-benzamide 
• 186312-78-7 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-N-ethyl-2-methoxy-N-(4-trifluoromethyl-benzyl)-benzamide 
• 185808-47-3 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-(4-trifluoromethoxy-benzyl)-benzamide 
• 185808-43-9 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-(2-trifluoromethyl-benzyl)-benzamide 
• 185808-41-7 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-(3-trifluoromethyl-benzyl)-benzamide 
• 185808-46-2 N-(4-tert-butyl-benzyl)-5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-benzamide 
• 186312-75-4 N-(4-tert-butyl-phenyl)-5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-benzamide 
• 185808-60-0 N-(4-dimethylamino-benzyl)-5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-benzamide 
• 185808-48-4 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-(4-methoxy-benzyl)-benzamide 
• 185808-61-1 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-(4-methyl-benzyl)-benzamide 

Relevant articles and documents

(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents

A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure- activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4- (trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.