78515-16-9Relevant articles and documents
Electricity Driven 1,3-Oxohydroxylation of Donor-Acceptor Cyclopropanes: a Mild and Straightforward Access to β-Hydroxy Ketones
Banerjee, Prabal,Maajid Taily, Irshad,Saha, Debarshi
supporting information, p. 5053 - 5057 (2021/09/30)
An unprecedented external oxidant-free electrochemical protocol for 1, 3-oxohydroxylation of donor-acceptor cyclopropane is disclosed. The strategy encompasses the activation of the labile π-electron cloud of the aryl ring to cleave the strained Csp3?Csp3 bond of cyclopropane to afford the β-hydroxy ketones via insertion of molecular oxygen. More significantly, based on the detailed mechanistic investigations and cyclic voltammetry experiments, a plausible mechanism is proposed.
Preparation method of methyl 5-formyl-2-methoxybenzoate
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Paragraph 0038; 0040; 0042; 0044, (2019/01/16)
The invention discloses a preparation method of methyl 5-formyl-2-methoxybenzoate. The preparation method comprises following steps: (1), preparation of methyl-2-methoxybenzoate; (2), preparation of methyl 5-formyl-2-methoxybenzoate. With the adoption of the method for loading an aldehyde group by urotropine after ester formation, the total yield can be increased to about 90%, the utilization rateof the raw materials is greatly increased, the cost is low, the operation is simple and convenient, and industrialization is facilitated.
1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
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Paragraph 0632; 0634, (2014/06/23)
Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.