311770-62-4Relevant articles and documents
Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor (PPAR) α
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, (2008/06/13)
The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor α (PPARα), and exhibit potent decreasing action on lipids in blood (cholesterol an
Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: Novel human PPARα-selective activators
Miyachi, Hiroyuki,Nomura, Masahiro,Tanase, Takahiro,Takahashi, Yukie,Ide, Tomohiro,Tsunoda, Masaki,Murakami, Koji,Awano, Katsuya
, p. 77 - 80 (2007/10/03)
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.