187326-67-6

Basic information

• Product Name: 4,6-DIBROMO ISATIN
• Synonyms: 4,6-DIBROMO ISATIN;4,6-Dibromo-1H-indole-2,3-dione;4,6-Dibromo-2,3-dihydro-1H-indole-2,3-dione;1H-Indole-2,3-dione,4,6-dibroMo-;4,6-BroMoisatin;4,6-DIBROMO-INDOLINE-2,3-DIONE;4,6-dibromoindoline-2,3-dione(WX142340)
• CAS NO: 187326-67-6
• Molecular Formula: C₈H₃Br₂NO₂
• Molecular Weight: 304.92
• Mol File: 187326-67-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 2.179g/cm³
• Refractive Index: 1.678
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4,6-DIBROMO ISATIN(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DIBROMO ISATIN(187326-67-6)
• EPA Substance Registry System: 4,6-DIBROMO ISATIN(187326-67-6)

Safety Data

• Hazardous Substances Data: 187326-67-6(Hazardous Substances Data)

Usage

General Description

4,6-Dibromo isatin is a chemical compound with the molecular formula C8H4Br2N2O2. It is a brominated derivative of isatin, which is a popular heterocyclic compound used in the synthesis of various pharmaceuticals and agrochemicals. 4,6-Dibromo isatin has been studied for its potential applications in organic synthesis and medicinal chemistry. It has been found to exhibit antimicrobial, antitumor, and anti-inflammatory activities, making it a promising candidate for drug development. Additionally, 4,6-Dibromo isatin has shown potential as a corrosion inhibitor in metal surfaces and as a reagent in organic reactions. Its unique structure and diverse properties make it an important compound in the field of chemical research and development.

InChI:InChI=1/C8H3Br2NO2/c9-3-1-4(10)6-5(2-3)11-8(13)7(6)12/h1-2H,(H,11,12,13)

Upstream product

• 99910-50-6 4,6-dibromoindole 
• 626-40-4 3,5-dibromoaniline 
• 251109-83-8 C₁₃H₁₄Br₂N₂O₃ 
• 251109-81-6 5′,5′-dimethyl-5-nitrospiro[indoline-3,2′-[1,3]dioxan]-2-one 
• 251109-82-7 5-amino-5',5'-dimethylspiro[indoline-3,2'-[1,3]dioxan]-2-one 
• 91-56-5 indole-2,3-dione 
• 611-09-6 5-nitroisatin 
• 187326-66-5 3,5-dibromoisonitrosoacetanilide 

Downstream Products

• 1357155-61-3 C₁₇H₁₁Br₂F₂NO₃ 
• 1357155-62-4 C₁₇H₁₁Br₂F₂NO₄ 
• 1351337-09-1 (R)-S-(4-methoxyphenyl) 2-(4,6-dibromo-3-hydroxy-2-oxoindolin-3-yl)ethanethioate 
• 1351337-10-4 (R)-S-4-chlorophenyl 2-(4,6-dibromo-3-hydroxy-2-oxoindolin-3-yl)ethanethioate 
• 1351337-08-0 (R)-S-phenyl 2-(4,6-dibromo-3-hydroxy-2-oxoindolin-3-yl)ethanethioate 
• 1360771-88-5 (S)-S-phenyl 2-(4,6-dibromo-3-hydroxy-2-oxoindolin-3-yl)ethanethioate 
• 1351337-11-5 (R)-S-benzyl 2-(4,6-dibromo-3-hydroxy-2-oxoindolin-3-yl)ethanethioate 
• 1321619-65-1 (R)-4,6-dibromo-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one 
• 1245917-30-9 C₁₅H₉Br₂NO₂ 
• 1266333-62-3 C₂₁H₂₁Br₂NO₃S 

Relevant articles and documents

Visible-Light-Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides

Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. It should be noted that isatin derivatives are highly important for the synthesis of pharmaceuticals and bioactive compounds. Notably, this chemistry works excellently with N-protected and protection-free indoles. Additionally, this methodology can also be applied to dearomatise pyrrole derivatives to generate cyclic imides in a single step. Later this methodology was applied for the synthesis of four pharmaceuticals and a pesticide called dianthalexin B. Detailed mechanistic studies revealed the actual role of oxygen and photocatalyst.

Microwave assisted preparation of isatins and synthesis of (±)- convolutamydine-A

Microwave assisted preparation of a number of isatin derivatives is reported. A simple synthesis of (±)-convolutamydine-A, a potent compound against leukemia cells, is presented.

A modified Sandmeyer methodology and the synthesis of (±)-convolutamydine A

(±)-Convolutamydine A (5) has been prepared by it concise synthesis from 3,5-dibromoaniline using a modified Sandmeyer methodology. The modified Sandmeyer methodology has also been found to be beneficial for the synthesis of other α-isonitrosoacetanilides. The 4,6-dibromohydroxyoxindole nucleus was further confirmed by comparison with the isomeric 5,7-dibromohydroxyoxindole.