188120-25-4Relevant articles and documents
Total synthesis of progesterone receptor ligands, (-)-PF1092A, B and C
Tatsuta, Kuniaki,Yasuda, Shohei,Kurihara, Ken-Ichi,Tanabe, Kiyoshi,Shinei, Rie,Okonogi, Tsuneo
, p. 1439 - 1442 (2007/10/03)
Microbial metabolites (-)-PF1092A, B and C belonging to an eremophilane sesquiterpene group are synthesized from (R)-5-hydroxymethyl-2(5H)-furanone through the SnCl4 promoted cyclization of an α-keto methyl sulfone and dimethyl acetal followed by a Stork annulation which gives the octalone core.