18859-20-6

Basic information

• Product Name: N-methyl-N,3-diphenylpropanamide
• Synonyms: benzenepropanamide, N-methyl-N-phenyl-; N-Methyl-N,3-diphenylpropanamide
• CAS NO: 18859-20-6
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.3123
• Mol File: 18859-20-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 374.4°C at 760 mmHg
• Flash Point: 168.2°C
• Density: 1.096g/cm³
• Vapor Pressure: 8.39E-06mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: N-methyl-N,3-diphenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N,3-diphenylpropanamide(18859-20-6)
• EPA Substance Registry System: N-methyl-N,3-diphenylpropanamide(18859-20-6)

Safety Data

• Hazardous Substances Data: 18859-20-6(Hazardous Substances Data)

Upstream product

• 121-69-7 N,N-dimethyl-aniline 
• 501-52-0 3-Phenylpropionic acid 
• 4250-02-6 1-diazo-3-phenyl-2-propanone 
• 100-61-8 N-methylaniline 
• 151418-18-7 Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid 
• 645-45-4 hydrocinnamic acid chloride 
• 614-30-2 N-methyl-N-phenyl-benzenemethanamine 
• 120568-26-5 (E)-2-(methyl(phenyl)amino)-4-phenylbut-3-enenitrile 
• 147471-27-0 (Z)-2-(N-methylanilino)-4-phenyl-2-butenenitrile 
• 33603-46-2 (E)-N-methyl-N-phenylcinnamamide 
• 89585-53-5 3-chloro-N-methyl-N-phenylpropanamide 
• 98-80-6 phenylboronic acid 
• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 6273-94-5 N-methyl-N-phenylacrylamide 

Downstream Products

• 43125-06-0 1-cyclohexyl-3-phenyl-1-propanone 
• 108357-95-5 1,5-diphenylpent-1-yn-3-one 
• 20627-49-0 3-phenyl-propionic acid butyl ester 
• 29514-68-9 N-methyl-N-phenyl-3-phenylpropylamine 
• 6047-99-0 1-phenyloctan-3-one 
• 104-53-0 3-phenyl-propionaldehyde 

Relevant articles and documents

Enantioselective borohydride 1,4-reduction of α,β-unsaturated carboxamides using optically active cobalt(II) complex catalysts

The enantioselective borohydride reduction catalyzed by cobalt(II) complex was successfully applied to 1,4-reduction of β,β-disubstituted α,β-unsaturated carboxamides. In the presence of less than 1 mol% of optically active aldiminato cobalt(II) complex c

Cross-Dehydrogenative Cyclization-Dimerization Cascade Sequence for the Synthesis of Symmetrical 3,3′-Bisoxindoles

The synthesis of symmetrical 3,3′-bisoxindoles from simple acyclic β-oxoanilides is reported. The described method forges three new C-C bonds in a single step via a sequential Mn(OAc)3·2H2O mediated oxidative radical cyclization-fragmentation-dimerization process. The scope of this reaction is demonstrated in the preparation of a variety of 3,3′-bisoxindoles, as well as its application toward the formal synthesis of the Calycanthaceae alkaloid, (±)-folicanthine.

method for alpha-alkylation of acetamides and thioacetamides under catalysis of nickel

The invention discloses a method for alpha-alkylation of acetamide and thioacetamide under the catalysis of nickel. The method comprises the following steps: by taking a complex generated in situ by adivalent nickel salt and a phosphine ligand as a catalyst and primary alcohol as an alkylation reagent, performing alpha-alkylation reaction on acetamide or thioacetamide in an alkaline environment to prepare amide or thioamide. According to the alpha-alkylation reaction of acetamide and thioacetamide, the active catalyst can be generated in situ from a bivalent nickel salt and a phosphine ligand, so that the catalyst is prevented from being prepared in advance, the operation is simple and convenient, and experimental steps and cost are saved.