188591-76-6

Basic information

• Product Name: L-Phenylalanine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester
• CAS NO: 188591-76-6
• Molecular Formula: C15H18F3NO3
• Molecular Weight: 317.308
• Mol File: 188591-76-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester(188591-76-6)
• EPA Substance Registry System: L-Phenylalanine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester(188591-76-6)

Safety Data

• Hazardous Substances Data: 188591-76-6(Hazardous Substances Data)

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 16874-17-2 L-phenylalanine tert-butyl ester 
• 16367-71-8 t-butyl (RS)-phenylalaninate 
• 407-25-0 trifluoroacetic anhydride 
• 15100-75-1 L-phenylalanine tert-butyl ester hydrochloride 

Downstream Products

• 350-09-4 N-trifluoroacetyl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 16874-17-2 L-phenylalanine tert-butyl ester 
• 3081-28-5 D-phenylalanine tert-butyl ester 

Relevant articles and documents

Oxidative Amide Coupling from Functionally Diverse Alcohols and Amines Using Aerobic Copper/Nitroxyl Catalysis

The aerobic Cu/ABNO catalyzed oxidative coupling of alcohols and amines is highlighted in the synthesis of amide bonds in diverse drug-like molecules (ABNO=9-azabicyclo[3.3.1]nonane N-oxyl). The robust method leverages the privileged reactivity of alcohol

Chemoselective N-deprotection of tert-butyl 2-(trifluoroacetylamino) esters under PTC conditions: Synthesis of tert-butyl 2-aminocarboxylates

Trifluoroacetamide 1 is alkylated in good yields (77-83%) by tert-butyl 2-bromocarboxylates 3 under solid-liquid phase transfer catalysis (PTC) conditions [anhydrous K2CO3, triethyl(benzyl)ammonium chloride (TEBA; 10%), MeCN, 80°C]. The resulting tert-butyl 2-(trifluoroacetylamino) carboxylates 5 are chemoselectively hydrolysed in 75-95% yields to the corresponding tert-butyl 2-amino carboxylates, isolated as hydrochlorides 8, under liquid-liquid PTC conditions [CH2Cl2 or Et2O, aqueous 20% KOH, TEBA (10%), 25-40°C].