188612-53-5 Usage
Description
5-(Amino-1-(N-methyl Carbamoyl), also known as 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide, is a metabolite of Temozolomide (T017775), an imidazotetrazine alkylating agent and antineoplastic. It plays a significant role in the pharmaceutical industry due to its association with cancer treatment.
Uses
Used in Pharmaceutical Industry:
5-(Amino-1-(N-methyl Carbamoyl) is used as a metabolite for [application reason] in the pharmaceutical industry. It is derived from Temozolomide, an antineoplastic agent, which makes it a crucial component in the development and understanding of cancer treatment.
Used in Anticancer Applications:
In the field of oncology, 5-(Amino-1-(N-methyl Carbamoyl) is used as a metabolite for enhancing the effectiveness of cancer treatment. Its connection to Temozolomide, an alkylating agent, allows it to contribute to the inhibition of tumor growth and the progression of cancer.
Used in Research and Development:
5-(Amino-1-(N-methyl Carbamoyl) is also used as a research compound for further investigation into its potential applications and interactions with other pharmaceutical compounds. This research can lead to the development of new drugs and therapies for various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 188612-53-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,6,1 and 2 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 188612-53:
(8*1)+(7*8)+(6*8)+(5*6)+(4*1)+(3*2)+(2*5)+(1*3)=165
165 % 10 = 5
So 188612-53-5 is a valid CAS Registry Number.
188612-53-5Relevant articles and documents
PROCESS FOR PREPARING HIGHLY PURE TEMOZOLOMIDE
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Page/Page column 15-17, (2020/10/18)
The present invention provides a commercially viable process for preparation of highly pure Temozolomide (VI), which is useful in the treatment of cancer. The invention also provides an economically viable process for an intermediate compound of formula III useful in the process for preparing Temozolomide.
TEMOZOLOMIDE PROCESS
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Page/Page column 12, (2018/07/29)
The present invention relates to improved process for the preparation of Temozolomide Formula I. Said Temozolomide (I) is useful in the treatment of cancer.
A tiemoazoleamine and method for synthesizing intermediate
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Paragraph 0006; 0012; 0027; 0032-0035, (2019/02/02)
The invention discloses a modified optimized synthetic method for temozolomide and an intermediate thereof. The synthetic method is characterized in that a new oxidation ring-closing reagent is introduced for a reaction with lithium chloride and sodium nitrite in an aqueous solution, and the synthetic method helps to improve the yield of the reaction, increase the controllability on the reaction and avoid usage of methyl isocyanate with relatively high toxicity.