5819-21-6

Basic information

• Product Name: ETHYL-4-NITROPHENYLCARBAMATE
• Synonyms: ETHYL-4-NITROPHENYLCARBAMATE
• CAS NO: 5819-21-6
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16
• Mol File: 5819-21-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 160.5-162.0 °C(Solv: methanol (67-56-1); ethanol (64-17-5); octane (111-65-9))
• Boiling Point: 316.6°Cat760mmHg
• Flash Point: 145.3°C
• Appearance: /
• Density: 1.327g/cm³
• Vapor Pressure: 0.000405mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: 10.67±0.46(Predicted)
• CAS DataBase Reference: ETHYL-4-NITROPHENYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL-4-NITROPHENYLCARBAMATE(5819-21-6)
• EPA Substance Registry System: ETHYL-4-NITROPHENYLCARBAMATE(5819-21-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5819-21-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N2O4/c1-9-8(11)14-7-4-2-6(3-5-7)10(12)13/h2-5H,1H3,(H,9,11)

Upstream product

• 100-02-7 4-nitro-phenol 
• 624-83-9 methyl isocyanate 
• 6642-30-4 methyl N-methylcarbamate 
• 25070-81-9 allyl N-methylcarbamate 
• 30379-59-0 benzyl N-methylcarbamate 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 74-89-5 methylamine 
• 5070-13-3 bis-(p-nitrophenyl) carbonate 

Downstream Products

• 6135-36-0 methyl(n-butyl)urea 
• 1025358-49-9 2'-O-(tert-butyldimethylsilyl)-3',5'-dideoxy-3'-[(ethoxycarbonyl)methyl]-5'-[(N-methylcarbamoyl)amino]-N⁶-(N-phenylcarbamoyl)adenosine 
• 524071-54-3 allyl ((2R,3S)-2-{2-[4-({[(methylamino)-carbonyl]-amino}-methyl)-phenyl]-2-oxoethyl}-4-oxo-3-{(1R)-1-[(trimethylsilyl)-oxy]-ethyl}-azetidin-1-yl) (triphenylphosphoranilidene) acetate 
• 524071-49-6 allyl ((2R,3S)-3-((1R)-1-{[(allyloxy)-carbonyl]-oxy}-ethyl)-2-{2-[3-({[(methylamino)-carbonyl]-amino}-methyl)-phenyl]-2-oxoethyl}-4-oxoazetidin-1-yl) (triphenylphosphoranilidene) acetate 
• 188612-53-5 5-amino-N₁-methyl-1H-imidazole-1,4-dicarboxamide 
• 1618136-82-5 Cl^(1-)*C₂₅H₃₁N₄O₂⁽¹⁺⁾ 
• 1618136-81-4 C₂₄H₂₉N₄O₃⁽¹⁺⁾*Cl^(1-) 
• 1401415-51-7 5'-deoxy-2',3'-bis-O-benzoyl-5'-[(N-methylcarbamoyl)amino]adenosine 
• 1401415-43-7 5'-deoxy-2',3'-bis-O-isobutyryl-5'-[(N-methylcarbamoyl)amino]-N⁶-(N-phenylcarbamoyl)-adenosine 
• 1401415-42-6 5'-deoxy-2',3'-bis-O-benzoyl-5'-[(N-methylcarbamoyl)amino]-N⁶-(N-phenylcarbamoyl)-adenosine 
• 1401415-41-5 2',3'-bis-O-acetyl-5'-deoxy-5'-[(N-methylcarbamoyl)amino]-N⁶-(N-phenylcarbamoyl)-adenosine 
• 1401415-34-6 C₃₇H₆₂N₈O₅Si₂ 
• 1401415-32-4 2',3'-bis-O-tert-butyldiphenylsilyl-5'-deoxy-5'-[(N-methylcarbamoyl)amino]-N⁶-(N-phenylcarbamoyl)adenosine 
• 1401415-31-3 5'-deoxy-2',3'-bis-O-triethylsilyl-5'-[(N-methylcarbamoyl)amino]-N⁶-(N-phenylcarbamoyl)adenosine 

Relevant articles and documents

Selective modification of streptozotocin at the C3 position to improve its bioactivity as antibiotic and reduce its cytotoxicity towards insulin-producing β cells

With the increasing resistance of bacteria to current antibiotics, novel compounds are urgently needed to treat bacterial infections. Streptozotocin (STZ) is a natural product that has broad-spectrum antibiotic activity, albeit with limited use because of

Transesterification of alkyl carbamate to aryl carbamate : Effect of varying the alkyl group

Phosphorus oxychloride mediated transesterification of four alkyl N-methylcarbamates to several aryl N-methylcarbamates has been studied. Best yields are obtained from benzyl N-methylcarbamate.

A convenient method for the synthesis of activated N-methylcarbamates

An investigation of methods to efficiently prepare activated N-methylcarbamates is reported. N-(Methylcarbamoyloxy)succinimide (3a), aryl N-methylcarbamates 3b-d and 2,2,2-trifluoro-1-(trifluoromethyl)ethyl N-methylcarbamate (3e) have been prepared in 70-80% yields from the corresponding chloroformates 5a-e, which were prepared as crystalline solids by the condensation of trichloromethylchloroformate (1) or bis(trichloromethyl)carbonate (2) with hydroxy compounds 4a-e in high yields.