188826-32-6 Usage
General Description
5-Fluoro-4-chromanone is a chemical compound with the formula C9H7FO2. It is a fluorinated derivative of 4-chromanone, which is a heterocyclic compound that contains a chromanone core structure. 5-Fluoro-4-chromanone has been studied for its potential biological activities and has been used as a building block in the synthesis of various pharmaceutical compounds. It is known to possess anti-cancer, anti-inflammatory, and antioxidant properties. The compound is also used in the development of novel drug molecules and has shown promise in preclinical studies as a potential therapeutic agent for various diseases. Its unique chemical properties make it a valuable tool for medicinal chemistry research and drug discovery efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 188826-32-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,8,2 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 188826-32:
(8*1)+(7*8)+(6*8)+(5*8)+(4*2)+(3*6)+(2*3)+(1*2)=186
186 % 10 = 6
So 188826-32-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H7FO2/c10-6-2-1-3-8-9(6)7(11)4-5-12-8/h1-3H,4-5H2
188826-32-6Relevant articles and documents
Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor
Battisti, Umberto M.,Corrado, Sandra,Sorbi, Claudia,Cornia, Andrea,Tait, Annalisa,Malfacini, Davide,Cerlesi, Maria Camilla,Calò, Girolamo,Brasili, Livio
supporting information, p. 973 - 983 (2014/07/08)
A series of triazospirodecanone derivatives were synthesized as potential NOP ligands. 8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (4) and its 5-fluoro analogue (18) proved to be active as agonists with EC50 values in the submicromolar range. Single enantiomers of compound 4 were separated and tested as NOP agonists; the eutomer R-(+)-4 showed a pEC 50 of 7.34. Finally docking studies were performed on the NOP receptor to identify the most significant stereospecific interactions.
SPIROAMINODIHYDROTHIAZINE DERIVATIVES
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Page/Page column 61, (2010/04/03)
A compound represented by the general formula (I): or a pharmaceutically acceptable salt thereof, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer- type dementia.
