18922-88-8Relevant articles and documents
Reactions of Iron Porphyrins with Methyl Radicals
Brault, D.,Neta, P.
, p. 2705 - 2710 (1981)
The reactions of methyl radicals with ferric, ferrous, and iron-free deuteroporphyrin have been investigated in neutral and alkaline water-2-propanol mixtures.Steady-state radiolysis of methyl chloride saturated solutions of ferric deuteroporphyrin, or ch
One-Electron Reduction of Ferrideuteroporphyrin IX and Reaction of the Oxidized and Reduced Forms with Chlorinated Methyl Radicals
Brault, D.,Bizet, C.,Morliere, P.,Rougee, M.,Land, E. J.,et al.
, p. 1015 - 1020 (1980)
α-Hydroxyisopropyl radicals prepared by fast electron irradiation of aqueous solutions containing 2-propanol and acetone were found to reduce monomeric ferrideuteroporphyrin to ferrodeuteroporphyrin with a rate constant of 3.7*108 M-1 s-1.Relaxation of the coordination sphere is found to proceed with a rate constant k > 5*105 s-1.Irradiation of such solution in the added presence of various concentrations of CCl4, CHCl3, or CH2Cl2 enable studies to be made of the reactions of ferri- and ferrodeuteroporphyrin with chlorinated methyl radicals.No reaction of ferrideuterroporphyrin with CCl3 could be detected (k 6 M-1 s-1).For ferrrodeuteroporphyrin it appears that a rapid reaction (k = (2 +/- 1)*109 M-1 s-1) gives a complex (DPFeII-CH3-nCln) which undergoes further reaction as shown by transient spectral modifications.These results suggest that ferrous cytochrome P450 is likely to react rapidly with chlorinated radicals.A model for the toxicity and detoxification of CCl4 is proposed.
