19018-24-7

Basic information

• Product Name: 2-(1-HYDROXYETHYL)BENZIMIDAZOLE
• Synonyms: IFLAB-BB F0853-0195;CHEMBRDG-BB 5155310;AKOS BBS-00001406;AKOS BC-1561;1-(BENZIMIDAZOL-2-YL)ETHANOL;1-(1H-1,3-BENZIMIDAZOL-2-YL)-1-ETHANOL;1-(1H-BENZIMIDAZOL-2-YL)ETHANOL;1-(1H-BENZOIMIDAZOL-2-YL)-ETHANOL
• CAS NO: 19018-24-7
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• EINECS: 1.285 g/cm³
• Product Categories: BENZIMIDAZOLE;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines
• Mol File: 19018-24-7.mol
• Article Data: 45

Chemical Properties

• Melting Point: 178°C
• Boiling Point: 389℃
• Flash Point: 189℃
• Appearance: white solid
• Density: 1.285
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.58±0.10(Predicted)
• CAS DataBase Reference: 2-(1-HYDROXYETHYL)BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-HYDROXYETHYL)BENZIMIDAZOLE(19018-24-7)
• EPA Substance Registry System: 2-(1-HYDROXYETHYL)BENZIMIDAZOLE(19018-24-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: KJ7527500
• HazardClass: IRRITANT
• Hazardous Substances Data: 19018-24-7(Hazardous Substances Data)

Usage

General Description

2-(1-Hydroxyethyl)benzimidazole is a chemical compound with the molecular formula C9H10N2O. It belongs to the class of benzimidazoles, which are heterocyclic aromatic compounds that contain a benzene ring fused to an imidazole ring. The addition of a hydroxyethyl group to the benzimidazole structure modifies its chemical properties, making it useful in various industrial applications. 2-(1-HYDROXYETHYL)BENZIMIDAZOLE is commonly used as a corrosion inhibitor in metalworking fluids and lubricants, where it helps protect metal surfaces from rust and corrosion. It is also employed as a stabilizer in plastics and polymers to prevent degradation due to exposure to heat and UV radiation. Additionally, 2-(1-Hydroxyethyl)benzimidazole has been studied for its potential medicinal properties, including its antioxidant and anti-inflammatory effects.

Upstream product

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Downstream Products

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• 341504-06-1 1-(1H-benzoimidazol-2-yl)-2,3-dibromo-3-(4-dimethylamino-phenyl)-propan-1-one 
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Relevant articles and documents

Design and structure-activity relationships anticandidosic of diazaheteroaryl functionalized by Micha?l acceptors

Benzimidazole and imidazopyridine heterocycles associated with Micha?l acceptors have shown strong anticandidosic potential in our previous work. After a decade of research, we have designed, synthesized and evaluated the anticandidosic activities of seve

Preparation method of thiabendazole intermediate

The invention provides a preparation method of a thiabendazole intermediate. The method uses a raw material containing o-phenylenediamine to prepare the thiabendazole intermediate shown as a formula (1), and comprises the following steps: in an acidic environment, carrying out condensation reaction on the raw material containing o-phenylenediamine to obtain a crude product 1; carrying out halogenation reaction on the crude product 1 to obtain a crude product 2; and carrying out decarboxylation reaction on the crude product 2, and purifying to obtain the thiabendazole intermediate. According tothe invention, the method is low in raw material cost, simple in synthetic route, inapplicable to catalysts, recyclable in solvent, almost zero in emission of three wastes, mild in reaction condition, simple to operate and suitable for modern industrial production, and the influence on the environment is avoided, and the yield is as high as 80% or above. R is Cl or Br.

Design, synthesis, and biological evaluation of aromatic amide-substituted benzimidazole-derived chalcones. The effect of upregulating TP53 protein expression

A series of benzimidazole-derived chalcones containing aromatic amide substituent were designed and synthesized. All of the chalcone compounds were tested for their in vitro antitumor activity against human cancer cell lines (HCT116, HepG2, A549, and CRL-5908). The antiproliferative activity of compounds 3, 6, 9, 14, 15, 16 against HCT116 cells was significantly better than that that of 5-Fluorouracil (IC50: 94.63 μM). The antitumor activity of these compounds showed obvious differences between the wild type HCT116 and mutant HCT116 (TP53-/-) cells. A preliminary mechanistic study suggested that these compounds act by upregulating the expression of TP53 protein in tumor cells without inhibiting the MDM2-TP53 interaction.