190966-43-9

Basic information

• Product Name: 2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one
• Synonyms: 2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one
• CAS NO: 190966-43-9
• Molecular Weight: 283.189
• Mol File: 190966-43-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one(190966-43-9)
• EPA Substance Registry System: 2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one(190966-43-9)

Safety Data

• Hazardous Substances Data: 190966-43-9(Hazardous Substances Data)

Upstream product

• 104-95-0 (4-bromophenyl)thioanisole 
• 226703-16-8 2-Bromo-3-ethoxy-2-cyclopenten-1-one 
• 60822-47-1 4-bromothio-anisole 
• 10481-34-2 2-bromo-2-cyclopenten-1-one 
• 22627-70-9 3-ethoxycyclopent-2-en-1-one 
• 3859-41-4 1,3-cyclopentadione 

Downstream Products

• 190966-44-0 2-bromo-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1-one 
• 190966-40-6 3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)-2-cyclopenten-1-one 
• 212126-32-4 2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1-one 
• 228717-97-3 2-(3',5'-difluorophenyl)-3-(4'-methylthiophenyl)cyclopent-2-en-1-one 

Relevant articles and documents

Efficient syntheses of 2-(3',5'-difluorophenyl)-3-(4'- methylsulfonylphenyl)-cyclopent-2-enone, a potent COX-2 inhibitor

2-(3',5'-Difluorophenyl)-3-(4'-methylsulfonylphenyl)cyclopent-2-enone (1) displays high selectivity and potency against COX-2. Three efficient syntheses of this diarylcyclopentenone are described. The first approach employs a Suzuki coupling reaction as the key step while the second synthesis features an intramolecular Friedel-Crafts acylation. The third, and preferred route to this compound involves a sequential malonate alkylation and acylation and ring-closure sequence.

Pyridinyl-2-cyclopenten-1-ones as selective cyclooxygenase-2 inhibitors

The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I.

3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.