19121-58-5 Usage
Description
Solasonine, also known as α-Solasonine, is a natural glycoalkaloid compound found in several species of Solanum, including S. aviculare, S. sodomeum, S. verbascifolium, and S. xanthocarpum. It is characterized by its ability to inhibit Gli-mediated transcriptional activity and has a crystalline structure with a melting point of 245-250°C (dec.). Solasonine can form various salts, such as hydrochloride, picrate, picrolonate, and the acetyl derivative, and undergoes alkaline hydrolysis to yield solasodine along with one mole each of galactose, glucose, and rhamnose. When dissolved in concentrated H2SO4, it exhibits a crimson color with a brown fluorescence.
Uses
Used in Pharmaceutical Applications:
Solasonine is used as a bioactive compound for its inhibitory effects on Gli-mediated transcriptional activity. This property makes it a potential candidate for the development of drugs targeting various diseases and conditions related to the dysregulation of Gli-mediated transcription.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Solasonine can be utilized as a component in drug delivery systems to enhance the bioavailability and therapeutic outcomes of medications. Its unique properties may allow for the development of novel drug formulations that can improve the efficacy and safety of treatments.
Used in Research and Development:
Solasonine's ability to inhibit Gli-mediated transcriptional activity makes it a valuable tool in research and development for understanding the underlying mechanisms of various diseases and the development of targeted therapies. It can be used in laboratory settings to study the effects of this compound on cellular processes and to identify potential applications in medicine.
Used in Natural Product Development:
As a natural glycoalkaloid, Solasonine can be incorporated into the development of natural products, such as dietary supplements or nutraceuticals, that aim to provide health benefits by targeting specific biological pathways. Its unique properties may contribute to the development of novel products with potential therapeutic applications.
Purification Methods
Solasonine crystallises from aqueous 80% dioxane or MeOH in needles. [Bell & Briggs J Chem Soc 1 1942, Briggs et al. J Chem Soc 4645 1961, Briggs et al. J Chem Soc 2848 1963.] The picrate crystallises from 30% aqueous EtOH with m 197-198o(dec) [Briggs & Cambie J Chem Soc 1422 1958]. [Beilstein 27 III/IV 2006.]
References
Oddo et a/., Gazzetta, 35, 27 (1905)
Levi., J. Soc. Chem. Ind., 49, 395T (1930)
Briggs., Nature, 144, 247 (1939)
Briggs.,J. Chem. Soc., 3 (1942)
Briggs, Vining., ibid, 2809 (1953)
Hayes, Scaforth., ibid, 74S (1963)
Check Digit Verification of cas no
The CAS Registry Mumber 19121-58-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,1,2 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 19121-58:
(7*1)+(6*9)+(5*1)+(4*2)+(3*1)+(2*5)+(1*8)=95
95 % 10 = 5
So 19121-58-5 is a valid CAS Registry Number.
InChI:InChI=1/C45H73NO16/c1-19-8-13-45(46-16-19)20(2)30-27(62-45)15-26-24-7-6-22-14-23(9-11-43(22,4)25(24)10-12-44(26,30)5)57-42-39(61-40-36(54)34(52)31(49)21(3)56-40)38(33(51)29(18-48)59-42)60-41-37(55)35(53)32(50)28(17-47)58-41/h6,19-21,23-42,46-55H,7-18H2,1-5H3/t19-,20+,21+,23+,24-,25+,26+,27+,28-,29-,30+,31+,32-,33+,34-,35+,36-,37-,38+,39-,40+,41+,42-,43+,44+,45-/m1/s1
19121-58-5Relevant articles and documents
spiral steroid alkali alkane xylosides alkloids method for the synthesis of (by machine translation)
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Paragraph 0119; 0120, (2017/04/11)
The invention discloses a convergent spiral steroid alkali alkane xylosides alkaloid chemical synthesis method, the method comprises the following steps: (a) the 3?Hydroxy acyl silicon-based or for the protection of sapogenin spiral steroid (II) into the corresponding 16?Acetoxy?22?Carbonyl?26?(III) hydroxyl gallbladder gonanes; (b) 3?Hydroxy silicon-based or acyl group protection for 16?Acetoxy?22?Carbonyl?26?Preparation of sulfonic acid ester gallbladder gonanes (IV); (c) 3?Hydroxy silicon-based or acyl group protection for 16?Acetoxy?22?Carbonyl?26?Preparation of azide interior gonanes (V); (d) (VI) spiral steroid alkali alkane sapogenin the preparation; (e) acyl protecting spiral steroid alkali alkane xylosides alkloids preparation (VII); (f) spiral steroid alkali alkane xylosides alkloids (I) of the preparation. The preparation method of this invention simple process, high yield, has strong utility value. (by machine translation)
