191789-56-7Relevant articles and documents
Facile synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones: Via cyclization of N -alkoxy α-halogenoacetamides with N -(2-chloromethyl)aryl amides
Jin, Qiaomei,Zhang, Dongjian,Zhang, Jian
, p. 9708 - 9711 (2019)
A facile and efficient cyclization of N-alkoxy α-halogenoacetamides with N-(2-chloromethyl)aryl amides has been achieved for rapid access to 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-one derivatives (up to 95% yield). The intriguing features of this intermolecular cyclization include its mild reaction conditions and easy handling for scalable synthesis.