19212-42-1Relevant articles and documents
Hypervalent Iodine(III) Reagent Mediated Regioselective Cycloaddition of Aldoximes with Enaminones
Yoshimura, Akira,Jarvi, Melissa E.,Shea, Michael T.,Makitalo, Cody L.,Rohde, Gregory T.,Yusubov, Mekhman S.,Saito, Akio,Zhdankin, Viktor V.
, p. 6682 - 6689 (2019/11/02)
An efficient oxidative cycloaddition of enaminones with nitrile oxides generated in situ from respective aldoximes using hypervalent iodine reagents has been developed. Reactions of various aldoximes with enaminones in the presence of [hydroxy(tosyloxy)iodo]benzene involved the regioselective cycloaddition reaction resulting in the formation of the 3,4-disubstituted isoxazoles in moderate to good yields. Structures of several isoxazole products were confirmed by a single X-ray crystallography.
A novel synthesis of isoxazoles via 1,3-dipolar cycloaddition of nitrile oxides to acetyl acetone
Umesha,Kumar, K. Ajay,Rai, K. M. Lokanatha
, p. 1841 - 1846 (2007/10/03)
Nitrile oxides (2) isolated from the oxidative dehydrogenation of aldoximes (1) by chloramines-T react with acetyl acetone (3) to afford 4-acetyl-3-aryl-5-methyl isoxazoles (5) in good yield. All new compounds were characterized by IR, 1H NMR,