80572-11-8Relevant articles and documents
Isoxazolyl indolamines having anti-diabetic activity
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, (2008/06/13)
This disclosure describes novel compounds of the formula STR1 where m is 2, 3 or 4 X is hydrogen or hydroxy R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 and R3 each independently represent lower alkyl as defined above, or R2 and R3 together with N represent STR2 wherein n is 1, 2 or 3, and R4 represents hydrogen or lower alkyl as defined above, and R5 represents hydrogen, lower alkyl, phenyl or phenyl substituted with fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, with the proviso that when X is hydroxy, m is 3 or 4, or a pharmaceutically acceptable acid addition salt thereof, which are useful in the treatment of diabetes by inhibiting or impeding post-prandial hyperglycemia.