193269-78-2

Basic information

• Product Name: 1-Boc-3-(Amino)azetidine
• Synonyms: 1-Azetidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester;1-Boc-3-aminoazetidine ,97%;1-Boc-azetidin-3-amine;1-tert-Butoxycarbonyl-3-aminoazetidine;tert-Butyl 3-aminoazetidine-1-carboxylate, 3-Amino-1-(tert-butoxycarbonyl)azetidine, 3-Amino-1-(tert-butoxycarbonyl)azetane;1,1-DiMethylethyl 3-AMinoazetidine-1-carboxylate;3-AMino-1-azetidinecarboxylic Acid 1,1-DiMethylethyl Ester;tert-Butyl 3-AMino-1-azetidinecarboxylate
• CAS NO: 193269-78-2
• Molecular Formula: C₈H₁₆N₂O₂
• Molecular Weight: 172.22484
• Product Categories: Heterocycles;Miscellaneous Reagents;pharmacetical;Heterocycles series;Amines;Azetidine;Heterocyclic Compounds;Ring Systems
• Mol File: 193269-78-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 79-81 3mm
• Flash Point: 96.9 °C
• Appearance: /
• Density: 1.098 g/cm³
• Vapor Pressure: 0.0468mmHg at 25°C
• Refractive Index: 1.4650
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol, Water
• PKA: 8.29±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-3-(Amino)azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-(Amino)azetidine(193269-78-2)
• EPA Substance Registry System: 1-Boc-3-(Amino)azetidine(193269-78-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 34-51-22
• Safety Statements: 26-36-45-36/37/39
• RIDADR: 2735
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 193269-78-2(Hazardous Substances Data)

Usage

Chemical Properties

Clear Colourless to Pale Yellow Oil

InChI:InChI=1/C8H16N2O2/c1-8(2,3)12-7(11)10-4-6(9)5-10/h6H,4-5,9H2,1-3H3

Upstream product

• 429672-02-6 tert-butyl 3-azidoazetidine-1-carboxylate 
• 254454-54-1 tert-butyl-3-iodoazetidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 141699-55-0 tert-butyl 3-hydroxyazetidine-1-carboxylate 

Downstream Products

• 1239361-83-1 (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone 
• 1352934-25-8 tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate 
• 1210273-37-2 tert-butyl 3-aminoazetidine-1-carboxylate hydrochloride 
• 117546-56-2 1-isopropylazetidin-3-amine dihydrochloride 

Relevant articles and documents

CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY

The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

N-HETEROCYCLYL-SUBSTITUTED AMINO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Aminothiazole compounds with N-containing cycloalkyl at the 2-amino position which are represented by the Formula (I), or a pharmaceutically acceptable prodrug of said compound, or pharmaceutically acceptable salt of said compound, modulate and/or inhibit the cell proliferation and activity of protein kinases.

Pharmaceutically active pyrrolidine derivatives

The present invention is related to pyrrolidine derivatives of formula (I). Said compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine derivatives of formula (I) are useful in the treatment and/or prevention of premature labor, premature birth and dysmenorrhea. In particular, the present invention is related to pyrrolidine derivatives displaying a substantial modulatory, notably an antagonist activity of the oxytocin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin, including premature labor, premature birth and dysmenorrhea. The present invention is furthermore related to novel pyrrolidine derivatives as well as to methods of their preparation, wherein X is selected from the group consisting of CR6R7, NOR6, NNR6R7; A is selected from the group consisting of —(C═O)—, —(C═O)—O—, —C(═NH)—, —(C═O)—NH—, —(C═S)—NH, —SO22—, —SO2NH—, —CH2—,B is either a group —(C═O)—NR8R9 or represents a heterocyclic residue having the formula (a) wherein Q is NR10, O or S; n is an integer selected of 0, 1 or 2; Y, Z and E form together with the 2 carbons to which they are attached a 5-6 membered aryl or heteroaryl ring.