19339-72-1

Basic information

• Product Name: 2-[(4-methoxyphenyl)amino]-1,2-diphenyl-ethanone
• Synonyms: 2-[(4-methoxyphenyl)amino]-1,2-diphenyl-ethanone
• CAS NO: 19339-72-1
• Molecular Formula: C₂₁H₁₉NO₂
• Molecular Weight: 317.38
• Mol File: 19339-72-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 506.3°Cat760mmHg
• Flash Point: 260°C
• Appearance: /
• Density: 1.174g/cm³
• Vapor Pressure: 2.25E-10mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: 2-[(4-methoxyphenyl)amino]-1,2-diphenyl-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-methoxyphenyl)amino]-1,2-diphenyl-ethanone(19339-72-1)
• EPA Substance Registry System: 2-[(4-methoxyphenyl)amino]-1,2-diphenyl-ethanone(19339-72-1)

Safety Data

• Hazardous Substances Data: 19339-72-1(Hazardous Substances Data)

Usage

Classification

Arylcyclohexylamine class of dissociative anesthetics

Effects

Hallucinogenic and sedative effects in animal studies

Mechanism of action

Potent blocker of the N-methyl-D-aspartate (NMDA) receptor
Involved in the transmission of pain signals and regulation of synaptic plasticity in the brain

Interactions

Known to interact with serotonin and dopamine receptors

Medical use

Not approved for medical use

Legal status

Classified as a designer drug and legally restricted in many countries

Primary uses

Recreational purposes and scientific research

InChI:InChI=1/C21H19NO2/c1-24-19-14-12-18(13-15-19)22-20(16-8-4-2-5-9-16)21(23)17-10-6-3-7-11-17/h2-15,20,22H,1H3

Upstream product

• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 63468-90-6 phenylglyoxylic acid potassium salt 
• 611-73-4 Benzoylformic acid 
• 4746-86-5 hydroxy-diphenyl-acetaldehyde 
• 134-81-6 benzil 
• 104-94-9 4-methoxy-aniline 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 13964-92-6 acetyl(tetracarbonyl)cobalt 
• 4198-96-3 2-[(E)-4-Methoxy-phenylimino]-1,2-diphenyl-ethanone 
• 4198-96-3 2-((4-methoxyphenyl)imino)-1,2-diphenylethan-1-one 
• 97-94-9 triethyl borane 
• 201230-82-2 carbon monoxide 

Downstream Products

• 23190-16-1 (1R,2S)-2-Amino-1,2-diphenylethanol 
• 212968-11-1 (1S,2R)-1,2-diphenyl-2-(4-methoxy-anilino)-ethan-1-ol 
• 21096-60-6 MS--desoxybenzoin 
• 1186242-40-9 2-amino-1-(4-methoxyphenyl)-4,5-diphenyl-1H-pyrrole-3-carbonitrile 
• 4198-96-3 2-((4-methoxyphenyl)imino)-1,2-diphenylethan-1-one 
• 89357-33-5 erythro-2-<(p-methoxyphenyl)amino>-1,2-diphenylethanol 
• 130162-54-8 1-(4-methoxyphenyl)-2,3-diphenyl-1H-indole 

Relevant articles and documents

The Acceleration of the Rearrangement of α-Hydroxy Aldimines by Lewis or Bronsted Acids

An efficient method was developed for the synthesis of α-amino ketones from α-hydroxy imines. The reaction occurs through an α-iminol rearrangement involving the migration of a substituent of the carbinol carbon to the imine carbon. The optimal catalysts were found to be silica gel or montmorillonite K 10, which effected migration of a variety of aryl and alkyl substituents in high yields. The rearrangement can also be carried out on imines generated in situ from aldehydes and amines in essentially the same yields as those from the preformed imines.

Chemoselective reduction of α-imino carbonyl compounds into α-amino carbonyl compounds with titanium tetraiodide

α-Imino carbonyl compounds are chemoselectively reduced with titanium tetraiodide to give α-amino carbonyl compounds in good to excellent yields.

Visible-Light-Induced Radical Acylation of Imines with α-Ketoacids Enabled by Electron-Donor-Acceptor Complexes

A visible-light-induced radical acylation of imines with α-ketoacids has been achieved, enabled by an electron-donor-acceptor (EDA) complex. This EDA complex-mediated process eradicates the use of a photocatalyst. Visible light is used as the sole promote

Br?nsted Base-Catalyzed Reductive Cyclization of Alkynyl α-Iminoesters through Auto-Tandem Catalysis

A novel reductive cyclization of alkynyl α-iminoesters was developed through auto-tandem catalysis with a Br?nsted base as the catalyst. The reaction system involves two mechanistically different elementary processes, both of which are efficiently catalyz