1943-88-0

Basic information

• Product Name: 4-METHYL-ISOPHTHALONITRILE
• Synonyms: 4-METHYL-ISOPHTHALONITRILE
• CAS NO: 1943-88-0
• Molecular Formula: C₉H₆N₂
• Molecular Weight: 142.16
• Mol File: 1943-88-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-METHYL-ISOPHTHALONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-ISOPHTHALONITRILE(1943-88-0)
• EPA Substance Registry System: 4-METHYL-ISOPHTHALONITRILE(1943-88-0)

Safety Data

• Hazardous Substances Data: 1943-88-0(Hazardous Substances Data)

Usage

General Description

4-Methyl-isophthalonitrile is a chemical compound with the formula C9H7N. It is a light yellow crystalline solid with a molecular weight of 129.16 g/mol. 4-METHYL-ISOPHTHALONITRILE is commonly used in the production of dyes, pigments, and polymers. It is also utilized as a raw material in the synthesis of various pharmaceuticals and agricultural chemicals. Due to its aromatic structure, 4-methyl-isophthalonitrile is a versatile building block in organic synthesis, and its derivatives have a wide range of industrial applications. It is important to handle this chemical with care, as it may be harmful if ingested or inhaled, and can cause skin and eye irritation upon contact.

Upstream product

• 31543-75-6 2,4-dibromotoluene 
• 75-76-3 tetramethylsilane 
• 10347-14-5 2-cyano-1,4-benzenedicarbonitrile 
• 920-68-3 heptamethyldisilazane 
• 85-01-8 phenanthrene 
• 124-40-3 dimethyl amine 
• 626-17-5 benzene-1,3-dicarbonitrile 
• 121-45-9 phosphorous acid trimethyl ester 
• 95-73-8 2,4-dichlorotoluene 
• 544-92-3 copper(I) cyanide 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 17201-43-3 4-cyanobenzyl bromide 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 42872-74-2 3-bromo-4-methyl-benzonitrile 

Downstream Products

• 50670-74-1 4-bromomethylisophthalonitrile 
• 23038-61-1 dimethyl 4-methylbenzene-1,3-dicarboxylate 
• 1417404-25-1 C₂₆H₂₂F₂N₂O₃ 
• 1417403-96-3 4-[2-(3-chlorophenyl)ethyl]isophthalic acid dimethyl ester 
• 1417404-26-2 C₂₈H₂₇F₂N₃O₃ 
• 1417404-27-3 8-((3-benzamido-4-fluorophenyl)amino)-N-(2-morpholinoethyl)-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulene-3-carboxamide 
• 1417404-28-4 8-((2,4-difluorophenyl)amino)-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulene-3-carboxylic acid 
• 1417404-29-5 C₂₂H₁₆F₂N₂O₂ 
• 1417404-30-8 C₂₃H₁₈F₂N₂O₂ 
• 1417404-31-9 C₃₀H₃₀F₂N₂O₂ 
• 1417404-32-0 C₂₄H₁₉F₃N₂O₂ 
• 1417404-33-1 C₂₄H₁₉ClF₂N₂O₂ 
• 1417404-34-2 C₂₅H₂₂F₂N₂O₂S 
• 1417404-35-3 C₂₅H₂₂F₂N₂O₃ 

Relevant articles and documents

Preparation of polyfunctional nitriles by the cyanation of functionalized organozinc halides with p-toluenesulfonyl cyanide

Various alkyl, alkenyl, akynyl, benzylic, aromatic or heterocyclic organozinc halides bearing functional groups such as an ester, a boronic ester, a cyanide, a halide or a trialkoxysilyl group react under mild conditions with p-toluenesulfonyl cyanide affording polyfunctional nitriles in 69-93% yields.

Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication

An early lead from the AMD070 program was optimized and a structure-activity relationship was developed for a novel series of heterocyclic containing compounds. Potent CXCR4 antagonists were identified based on anti-HIV-1 activity and Ca2+ flux

DIPEPTIDYL PEPTIDASE-IV INHIBITORS

The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.