19620-90-7

Basic information

• Product Name: Ethanone,1-(5-bromo-1H-indol-3-yl)-
• Synonyms: Ketone,5-bromoindol-3-yl methyl (8CI);1-(5-Bromo-1H-indol-3-yl)ethanone;3-Acetyl-5-bromo-1H-indole
• CAS NO: 19620-90-7
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.08062
• Product Categories: Indole
• Mol File: 19620-90-7.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 388.995 °C at 760 mmHg
• Flash Point: 189.058 °C
• Appearance: /
• Density: 1.592 g/cm³
• CAS DataBase Reference: Ethanone,1-(5-bromo-1H-indol-3-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone,1-(5-bromo-1H-indol-3-yl)-(19620-90-7)
• EPA Substance Registry System: Ethanone,1-(5-bromo-1H-indol-3-yl)-(19620-90-7)

Safety Data

• Hazardous Substances Data: 19620-90-7(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(5-bromo-1H-indol-3-yl)- is a chemical compound with a molecular formula C10H8BrNO. It is a derivative of indole, which is a heterocyclic aromatic organic compound. This particular compound contains a 5-bromo-1H-indole group, which consists of a five-membered ring of carbons and nitrogen with a bromine atom attached. This chemical may have applications in pharmaceuticals, organic synthesis, and medicinal chemistry due to its structural features and potential biological activity. Its precise uses and properties would need to be determined through further research and experimentation.

Upstream product

• 506-93-4 guanidine nitrate 
• 10075-50-0 5-bromo-1H-indole 
• 1020722-10-4 3-(5-bromo-1H-indol-3-yl)-3-oxopropanenitrile 
• 1363843-19-9 C₁₁H₉BrN₂O₂ 
• 127-19-5 N,N-dimethyl acetamide 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 815-57-6 3-Methyl-2,4-pentanedione 

Downstream Products

• 121963-43-7 1-(5-bromo-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone 
• 265111-01-1 1-(5-bromo-1-tosyl-1H-indol-3-yl)ethan-1-one 
• 341998-57-0 (E)-1-(5-bromo-1-tosyl-1H-indol-3-yl)-3-(dimethylamino)prop-2-en-1-one 
• 213473-00-8 Meridianin C 

Relevant articles and documents

Synthesis and antibacterial evaluation of (E)-1-(1H-indol-3-yl) ethanone O-benzyl oxime derivatives against MRSA and VRSA strains

Infections caused due to multidrug resistant organisms have emerged as a constant menace to human health. Even though numerous antibiotics are currently available for treating infectious diseases, a great number of bacterial strains have acquired resistance to many of them. Among these, infections caused due to Staphylococcus aureus are predominant in adult and paediatric population. Indole is a prominent chemical scaffold found in many pharmacologically active natural products and synthetic drugs. A number of oxime ether containing compounds have attracted attention of researchers owing to their interesting biological properties. Current work details the synthesis of indole containing oxime ether derivatives and their evaluation for antimicrobial activity against a panel of bacterial and mycobacterial strains. Synthesized compounds demonstrated good to moderate activity against drug-resistant S. aureus including resistant to vancomycin. Among all, compound 5h was found to possess potent activity against susceptible as well as MRSA and VRSA strains of S. aureus with MIC of 1 μg/mL and 2–4 μg/mL respectively. In addition, compound 5h was found to be non-toxic to Vero cells and exhibited good selectivity index of >40. Further, 5h, E-9a and E-9b possessed good biofilm inhibition against S. aureus. With these assuring biological properties, synthesized compounds could be potential prospective antimicrobial agents.

Imidazolium Triflate Ionic Liquid Improves the Activity of ZnCl2 in the Synthesis of Pyrroles and Ketones

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A radical addition and cyclization relay promoted by Mn(OAc)3?2H2O: Synthesis of 1,2-oxaphospholoindoles and mechanistic study

Novel and efficient Mn(OAc)3?2H2O promoted radical addition-[4 + 1] cyclization relay of 3-indolymethanols and phosphites was disclosed, which afforded 1,2-oxaphospholoindole derivatives in moderate to good yields. Based on the experimental and computational studies, a mechanism involving radical addition and intramolecular cyclization cascade was proposed.