341998-57-0Relevant articles and documents
Discovery of novel indoleaminopyrimidine NIK inhibitors based on molecular docking-based support vector regression (SVR) model
Ye, Qing,Li, Qiu,Gao, Anhui,Ying, Huazhou,Cheng, Gang,Chen, Jing,Che, Jinxin,Li, Jia,Dong, Xiaowu,Zhou, Yubo
, p. 38 - 45 (2019/02/07)
A set of NF-κB-inducing kinase (NIK) inhibitors was used to develop a molecular docking-based QSAR model by using nonlinear regression method. The accuracy of the QSAR model was remarkably improved by integrating the docking scores and key interaction pro
Towards the syntheses of N-H and N-alkylated derivatives of meridianins
Simon, Ga?lle,Couthon-Gourves, Hélène,Haelters, Jean-Pierre,Corbel, Bernard,Kervarec, Nelly,Michaud, Fran?ois,Meijer, Laurent
, p. 793 - 801 (2008/03/29)
(Chemical Equation Presented) Novel N-H and N-alkylated derivatives of meridianins have been synthesized as potential antitumor agents by a two-step conversion of N-tosyl-3-acetylindoles or N-alkyl-3-acetylindoles to the corresponding enaminones using DMF-DMA, with or without added pyrrolidine. Further cyclization with guanidine gave the corresponding 2-aminopyrimidines. The structures of the compounds, thus obtained, were proved by 1H and 13C NMR spectroscopy, NOE experiments and X-ray analysis.
Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin
Fresneda, Pilar M.,Molina, Pedro,Delgado, Santiago,Bleda, Juan A.
, p. 4777 - 4780 (2007/10/03)
A nine-step synthesis of 9-amino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2- c]pyrimidine, a tricyclic ring system present in the marine alkaloids variolins is described. The natural marine products meridianins C-E have been synthesized for the first time starting from N-protected 3-acylindoles. (C) 2000 Elsevier Science Ltd.
